NCT01543477

Brief Summary

The purpose of this study is to estimate the incidence of Pure Red Cell Aplasia (PRCA), neutralising antibodies, lack of efficacy, and thromboembolic events under treatment with Retacrit™ (epoetin zeta) administered subcutaneously in patients with renal anaemia. The other key objective of this study is to obtain information on adverse drug reactions (ADR) associated with Retacrit™ (epoetin zeta), use of epoetin zeta during pregnancy and lactation and data on long term use.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
4,501

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2010

Longer than P75 for all trials

Geographic Reach
12 countries

179 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 7, 2010

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

February 21, 2012

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 5, 2012

Completed
8.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 29, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 29, 2020

Completed
Last Updated

October 1, 2020

Status Verified

September 1, 2020

Enrollment Period

9.8 years

First QC Date

February 21, 2012

Last Update Submit

September 29, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence Rate of Adverse Events of Special Interest

    Ongoing routine doctor visits for 156 weeks

    156 weeks

Secondary Outcomes (3)

  • Adverse drug reactions

    156 weeks

  • Information on treatment with Retacrit during pregnancy and lactation

    156 weeks

  • Data on long term use

    156 weeks

Study Arms (1)

Single group

Eligibility Criteria

Age0 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients currently under treatment with Retacrit (epoetin zeta) administered subcutaneously for renal anaemia.

You may qualify if:

  • Patients currently under treatment with Retacrit™ (epoetin zeta) administered subcutaneously for renal anaemia.
  • Informed consent given in writing after being provided with detailed information about the characteristics of this observation by the physician.
  • Patients expected to be available for 3 years of observation

You may not qualify if:

  • Any contraindications as per the current Summary of Product Characteristics (SPC) of Retacrit™

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (179)

MHAT "Dr. Tota Venkova"AD

Gabrovo, 5300, Bulgaria

Location

MHAT "Dr. Stamen Iliev"AD

Montana, 3400, Bulgaria

Location

UMHAT "Georgi Stranski" EAD

Pleven, 5800, Bulgaria

Location

Dutchmed Dialysis Clinic (in the building of 5 DCC)

Plovdiv, 4023, Bulgaria

Location

MHAT Plodiv AD

Plovdiv, 4027, Bulgaria

Location

MHAT "Dr. Bratan Shukerov" AD

Smolyan, 4700, Bulgaria

Location

Fifth MHAT EAD

Sofia, 1233, Bulgaria

Location

Acibadem City Clinic Tokuda Hospital EAD MHAT "Tokuda Hospital Sofia"

Sofia, 1407, Bulgaria

Location

University Hospital Lozenets

Sofia, 1407, Bulgaria

Location

UMHAT "Alexandrovska" EAD

Sofia, 1431, Bulgaria

Location

SHATPD "Prof. Ivan Mitev"EAD

Sofia, 1606, Bulgaria

Location

DCC "Sveta Anna" Sofia

Sofia, 1709, Bulgaria

Location

Kidney center - Medical center EOOD

Varna, 9010, Bulgaria

Location

UMHAT "Sveta Marina"EAD

Varna, 9010, Bulgaria

Location

County Hospital Cakovec

Čakovec, 40000, Croatia

Location

General Hospital Dubrovnik

Dubrovnik, 20000, Croatia

Location

General Hospital Karlovac

Karlovac, 47000, Croatia

Location

Health Center Labin

Labin, 52220, Croatia

Location

University Hospital Centre Osijek

Osijek, 31000, Croatia

Location

General Hospital Sibenik

Šibenik, 22000, Croatia

Location

Health Center Umag

Umag, 52470, Croatia

Location

University Hospital Centre Zagreb

Zagreb, 10000, Croatia

Location

University Hospital Merkur

Zagreb, 10000, Croatia

Location

Department of Renal Medicine Medicinerhuset 3 sal Aalborg University Hospital

Aalborg, 9100, Denmark

Location

Div. of Nephrology, Helsinki University HospitalHUS Kirurginen sairaala

Helsinki, 00290, Finland

Location

Pietarsaari Hospital Medical clinic

Jakobstad, 68601, Finland

Location

Kainuu Hospital

Kajaani, 87140, Finland

Location

CHU Amiens-Picardie Site Sud,, service de Nefrologie

Amiens (Salouel) Cedex 1, 80054, France

Location

CHU Amiens-Picardie Site Sud

Amiens (Salouel) Cedex 1, 80054, France

Location

Centre Hospitalier de Cahors

Cahors, 46005, France

Location

Aura Auvergne Chamalières

Chamalières, 63400, France

Location

Hospital Gabriel Montpied, Centre de Dialyse

Clermont-Ferrand, 63000, France

Location

35 Nephrologie Centre Medico Chirurgical de l'Europe

Le Port-Marly, 78560, France

Location

Polyclinique de la Louvière, Service Hemodialyse Nephrologie CHSA Maubeuge

Lille, 59800, France

Location

Aura Paris Plaisance

Paris, 75014, France

Location

Aura Notre Dame de Bon Secours

Paris, France

Location

Hopital de Rangueil, service de nephrologie

Toulouse, 31059, France

Location

Nephrologische Gemeinschaftspraxis

Alsfeld, 36304, Germany

Location

PHV Dialysezentrum Alsfeld

Alsfeld, 36304, Germany

Location

MVZ DaVita Alzey GmbH

Alzey, 55232, Germany

Location

Gemeinschaftspraxis Dr. Gööck & Dr. Anger

Arnstadt, 99310, Germany

Location

MVZ Bad Bevensen

Bad Bevensen, 29549, Germany

Location

Nephrologische Gemeinschaftspraxis

Bad Homburg, 61352, Germany

Location

Nephrologsiche Praxis

Bad König, 64732, Germany

Location

Internistische Praxis und Nephrologie

Bad Nauheim, 61231, Germany

Location

Nieren-und Hochdruckzentrum

Bad Wildungen, 34537, Germany

Location

Praxis F. Nierenkrankheiten/Tagesklinik

Berlin, 12627, Germany

Location

Gesundheitszentrum HSH

Berlin, 13051, Germany

Location

Alwall-Haus Dialysezentrum Berlin

Berlin, 13125, Germany

Location

Dialyse am Kurfürstendamm

Berlin, 14193, Germany

Location

Praxis Marsen

Cologne, 50937, Germany

Location

Dialyse Centrum Darmstadt

Darmstadt, 64295, Germany

Location

MVZ DaVita Dormagen GmbH

Dormagen, 41540, Germany

Location

KfH Nierenzentrum

Essen, 45136, Germany

Location

Praxis für Nephrologie

Frankenthal, 67227, Germany

Location

Nierenzentrum Heppenheim

Heppenheim an der Bergstrasse, 64646, Germany

Location

Praxisklinik-Dialysezentrum Herne DOKUSAN Gesellschaft für medizinische Studien mbH & Co. KG

Herne, 44623, Germany

Location

DaVita Elsterland

Herzberg, 04916, Germany

Location

Dialyse T. Menzer Homberg-Efze

Homberg (Efze), 34576, Germany

Location

Nephrologische Gemeinschaftspraxis und Dialysezentrum

Hoyerswerda, 02977, Germany

Location

Gemeinschaftspraxis Grahl und Johnen

Hürth-Hermülheim, 50354, Germany

Location

Westpfalz-Klinikum Kaiserslautern

Kaiserslautern, 67655, Germany

Location

Nieren- und Hochdruckzentrum Kiel

Kiel, 24106, Germany

Location

Medizinisches Versorgungszentrum MVZ Diaverum Kleve GmbH

Kleve, 47533, Germany

Location

Praxis Dres. Schoenwald und Beck

Langenfeld, 40764, Germany

Location

Nephrologische Praxis

Langenselbold, 63505, Germany

Location

Nierenzentrum Leverkusen

Leverkusen, 51373, Germany

Location

Dialysezentrum Ludwigslust

Ludwigslust, 19288, Germany

Location

Nephrologische Gemeinschaftspraxis

Lübeck, 23562, Germany

Location

Märkische Kliniken GmbH Klinikum Lüdenscheid

Lüdenscheid, 58515, Germany

Location

Dialysezentrum Stadtfeld

Magdeburg, 39108, Germany

Location

Nephrologische Praxis

Mayen, 56727, Germany

Location

Nephrologisches Zentrum

Mettmann, 40822, Germany

Location

Nephrologische Gemeinschaftspraxis

Mühlhausen, 99974, Germany

Location

MVZ DaVita Viersen GmbH

Nettetal, 41334, Germany

Location

ze:ro Dialysezentren und Gemeinschaftspraxis

Neustadt, 67433, Germany

Location

Nephrologisches- und Dialysezentrum Niebüll

Niebüll, 25899, Germany

Location

Klinikum Ernst von Bergmann

Potsdam, 14467, Germany

Location

Dialysezentrum

Quedlinburg, 06484, Germany

Location

Gemeinschaftspraxis Schuerfeld Moeller Henrich

Saarlouis, 66740, Germany

Location

Städtisches Klinikum Solingen Abt. Nephrologie - Innere Medizin

Solingen, 42653, Germany

Location

Dialysezentrum Tangermünde

Tangermünde, 39590, Germany

Location

Deutsche Klinik fuer Diagnostik Department of Nephrology

Wiesbaden, 65191, Germany

Location

General Hospital "Asklipeiio Voulas"

Voula, Attica, 166 73, Greece

Location

General Hospital of Rhodes

Agioi Apostoloi, 851 00, Greece

Location

General Hospital of Agios Nikolaos

Agios Nikolaos, Crete, 721 00, Greece

Location

Private Physician

Agrinio, 30100, Greece

Location

Office of Eleni Stefanopoulou/Private Physician

Aigáleo, 12243, Greece

Location

University General Hospital of Alexandroupoli

Alexandroupoli, 681 00, Greece

Location

Polikliniki Athinon

Athens, 10682, Greece

Location

Therapeutical Department "ATTIKO"

Athens, 113 62, Greece

Location

General Hospital Gennimata

Athens, 115 27, Greece

Location

General Hospital "Alexandra"

Athens, 115 28, Greece

Location

Errikos Ntinan Hospital

Athens, 11526, Greece

Location

Kyanos Stavros

Athens, 11526, Greece

Location

Aretaiion Hospital

Athens, 11528, Greece

Location

General University Hospital "ATTIKO"

Athens, 124 62, Greece

Location

General Hospital of Athens "A.Fleming"

Athens, 151 27, Greece

Location

Private Physician

Athens, 15235, Greece

Location

General Hospital of Chania

Chania, Crete, 733 00, Greece

Location

Didimoticho General Hospital

Didimoticho, 683 00, Greece

Location

Drama General Hospital

Drama, 661 00, Greece

Location

Edessa General Hospital

Edessa, 582 00, Greece

Location

General Hospital of Filiates

Filiátes, 463 00, Greece

Location

General Hospital of Grevena

Grevená, 511 00, Greece

Location

Kavala General Hospital

Kavala, 655 00, Greece

Location

General Hospital of Komotini Sismanogleio

Komotini, 691 00, Greece

Location

Private Physician

Kozani, 50100, Greece

Location

General Hospital of Kyparissia

Kyparissía, 245 00, Greece

Location

Private Physician

Lamia, 35100, Greece

Location

General University Hospital of Larisa

Larissa, 413 34, Greece

Location

General Clinic Eftichios Patsidis

Larissa, 41335, Greece

Location

General Hospital of Mesologgi

Mesologgi, 30200, Greece

Location

Private Physician

Nea Raidestos, Thessaloniki, 57001, Greece

Location

General Hospital Agios Andreas

Pátrai, 26 335, Greece

Location

General Hospital of Prolemaida

Ptolemaida, 502 00, Greece

Location

Serres general Hospital

Serres, 621 00, Greece

Location

AHEPA University Hospital

Thessaloniki, 546 36, Greece

Location

Ippokrateion General Hospital

Thessaloniki, 546 39, Greece

Location

Private Physician

Thessaloniki, 54642, Greece

Location

Private Physician

Thessaloniki, 56224, Greece

Location

Papageorgiou General Hospital

Thessaloniki, 564 29, Greece

Location

Private Physician

Thessaloniki, 56431, Greece

Location

"Diavalkaniko" Therareutical Center

Thessaloniki, 570 01, Greece

Location

Therapeutical Department of Thermi

Thessaloniki, 570 01, Greece

Location

Papanikolaou General Hospital

Thessaloniki, 570 10, Greece

Location

Private Physician

Véria, 59100, Greece

Location

Thessaliki Nosileutiki EPE

Volos, 38221, Greece

Location

Private Physician

Voula, 166 75, Greece

Location

Private Physician

Voula, 16673, Greece

Location

Merlin Park Dialysis Unit

Galway, Ireland

Location

Presidio ospesdaliero G.CRISCUOLI - UO DIALISI

Sant'Angelo dei Lombardi, Avellino, 83054, Italy

Location

Policlinico S. Marco di Istituti Ospedalieri Bergamaschi, U.O. Nefrologia e Dialisi

Zingonia- Osio Sotto, Bergamo, 24040, Italy

Location

"Presidio Ospedaliero" di Soverato - Servizio Dialisi

Soverato Marina, Catanzaro, 88068, Italy

Location

Presidio Ospedaliero S. GIUSEPPE e MELORIO AUSL CE/2 S. - U.O. Nefrologia e Dialisi

Santa Maria Capua Vetere, CE, 81055, Italy

Location

Azienda Ospedaliera S. Anna

Cona-Ferrara, Ferrara, 44124, Italy

Location

U.O.C. Nefrologia e Dialisi Ospedale degli Infermi-S.Miniato-USL 11 Empoli

San Miniato, PISA, 56027, Italy

Location

U.O. Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria Ospedali Riuniti

Ancona, 60020, Italy

Location

Ospedali Riuniti Anzio-Nettuno, Nefrologia e Dialisi ASL RMH

Anzio (RM), 00042, Italy

Location

Centro Dialisi Nefrologia - Ospedale S. Donato Arezzo

Arezzo, 52100, Italy

Location

Dipartimento di Nefrologia- Ospedale Mazzoni

Ascoli Piceno, 63100, Italy

Location

P.O. S.G. Moscati

Aversa (NA), 80031, Italy

Location

OSPEDALE MAGGIORE DI CHIERI - ASL TO 5 - S.C. Nefrologia e Dialisi

Chieri (TO), 10023, Italy

Location

AOU Careggi Hospital Firenze

Florence, 50134, Italy

Location

Ospedale della Misericordia USL9

Grosseto, 58100, Italy

Location

Dipartimento di Nefrologia Ospedale Versilia-Viareggio (Lucca)

Lido Di Camaiore (Lucca), 55043, Italy

Location

U.O. Nefrologia Lucca

Lucca, 55100, Italy

Location

U.O. Nefrologia e Dialisi ULSS12

Mestre, 30174, Italy

Location

Ospedale Niguarda Cà Granda - U.O. Nefrologia e Dialisi e Terapia Medica del Trapianto Renale

Milan, 20126, Italy

Location

Universita degli Studi di Napoli Federico II - Dipartimento di Patologia Sistematica

Naples, 80131, Italy

Location

A.O. MONALDI- Dept nephrology and Dialysis

Napoli, 80100, Italy

Location

Azienda Ospedaliera di Rilievo Nazionale "Antonio Cardarelli" - U.O. S. C. Nefrologia ed Emodialisi

Napoli, 80131, Italy

Location

Azienda Ospedaliera Universitaria della Università degli Studi della Campania "Luigi Vanvitelli"

Napoli, 80131, Italy

Location

ASL SA 1 P.O. Umberto I - U.O.C. di NEFROLOGIA E DIALISI

Nocera Inferiore (SA), 84014, Italy

Location

Ospedale SANTA MARIA DELLA PIETA - U.O.C. di NEFROLOGIA E DIALISI

Nola (NA), 80035, Italy

Location

Dipartimento di Medicina -DIMED- Policlinico Padova

Padua, 35128, Italy

Location

Fondazione S. Maugeri - IRCCS Clinica del Lavoro e della Riabilitazione,

Pavia, 27100, Italy

Location

UO Nefrologia, trapianti e dialisi SSN EDIFICIO 30A Azienda Ospedaliera Universitaria Pisa

PISA (Cisanello), 56124, Italy

Location

U.O.C. Nefrologia e Dialisi - Ospedale "Del Ceppo"

Pistoia, 51100, Italy

Location

U.O.C. Nefrologia e Dialisi Azienda Ospedaliera

San Sebastiano, 81100, Italy

Location

U.O.C. Nefrologia, Dialisi e Trapianto - Azienda Ospedaliera Universitaria Senese

Siena, 53100, Italy

Location

A.O.U. San Giovanni Battista di Torino - S.C. di Nefrologia, Dialisi e Trapianto

Torino, 10126, Italy

Location

Ospedale Martini - S.C. Nefrologia E Dialisi

Torino, 10141, Italy

Location

Ospedale San Giovanni Bosco - Struttura Complessa Nefrologia e Dialisi

Torino, 10154, Italy

Location

Hospital Universitario de Fuenlabrada

Fuenlabrada, Madrid, 28942, Spain

Location

Xanit Hospital Internacional

Benalmádena, Málaga, 29630, Spain

Location

Hospital Lluis Alcanyis

Xàtiva, Valencia, 46800, Spain

Location

Fundació Puigvert

Barcelona, 08025, Spain

Location

Hospital de Barcelona

Barcelona, 08034, Spain

Location

Hospital Universitario de Leon

León, 24071, Spain

Location

Hospital central della Cruz Roja

Madrid, 28003, Spain

Location

Hospital Universitario Central de Asturias

Oviedo, 33011, Spain

Location

Hospital Parc Taulí

Sabadell, 08208, Spain

Location

Hospital Virgen de la Concha

Zamora, 49022, Spain

Location

Karlskoga Lasarett

Karlskoga, 69181, Sweden

Location

Linköpings Universitetssjukhus

Linköping, 58185, Sweden

Location

Karolinska University Hospital

Stockholm, 14186, Sweden

Location

Njurmedicinska kliniken, Danderyds sjukhus

Stockholm, 18288, Sweden

Location

Kings College Hospital

London, SE5 9RS, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Pre-dose serum samples

MeSH Terms

Conditions

Breast Feeding

Condition Hierarchy (Ancestors)

Feeding BehaviorBehavior

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 21, 2012

First Posted

March 5, 2012

Study Start

July 7, 2010

Primary Completion

April 29, 2020

Study Completion

April 29, 2020

Last Updated

October 1, 2020

Record last verified: 2020-09

Data Sharing

IPD Sharing
Will not share

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

Locations