NCT01541917

Brief Summary

The purpose of this multi-site randomized clinical trial is to determine if an online coping skills training program will produce superior improvements in pain and health-related quality of life outcomes for adolescents with JIA relative to outcomes attained with reviewing online educational information about JIA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
305

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Jul 2012

Typical duration for phase_3

Geographic Reach
1 country

10 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 24, 2012

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 1, 2012

Completed
4 months until next milestone

Study Start

First participant enrolled

July 1, 2012

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2016

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2016

Completed
9 months until next milestone

Results Posted

Study results publicly available

March 9, 2017

Completed
Last Updated

March 9, 2017

Status Verified

January 1, 2017

Enrollment Period

3.8 years

First QC Date

February 24, 2012

Results QC Date

November 21, 2016

Last Update Submit

January 18, 2017

Conditions

Outcome Measures

Primary Outcomes (2)

  • Change in Pain Intensity

    Pain intensity was assessed by patient-self report using an electronic numeric rating scale ranging from 0-10, with 0 being the lowest value ("no pain") and 10 being the highest value ("very much pain").

    Baseline, post-treatment, 6-month follow-up, 12-month follow-up

  • Change in PedsQL Rheumatology Health-Related Quality of Life Total Score

    Health-related quality of life was measured by patient self-report using an electronic version of the PedsQL Rheumatology Module. Responses on this scale are transformed into a 0-100 scale, with 0 being the worst value for health-related quality of life and 100 being the best possible value for health-related quality of life.

    Pre-intervention, post-intervention, 6-month follow-up, 12-month follow-up

Secondary Outcomes (4)

  • Change in Medical Issues, Exercise, Pain and Social Support Questionnaire (MEPS) Education Score

    Pre-intervention, post-intervention, 6-month follow-up, 12-month follow-up

  • Change in Disease Activity

    Pre-intervention, post-intervention, 6-month follow-up, 12-month follow-up

  • Change in Children's Arthritis Self-Efficacy (CASE) Scores

    Pre-intervention, post-intervention, 6-month follow-up, 12-month follow-up

  • Change in Approach Coping

    Pre-intervention, post-intervention, 6-month follow-up, 12-month follow-up

Study Arms (2)

Web-based coping skills training

EXPERIMENTAL

Involves completion of a 12-week interactive, multi-component, multimedia online training that consists of instruction in specific self-management strategies, disease education, and social support.

Behavioral: Web-based coping skills training

Online disease education

ACTIVE COMPARATOR

Involves viewing 12 educational websites about Juvenile Idiopathic Arthritis over the course of 12 weeks.

Behavioral: Online disease education

Interventions

This intervention comprises a 12-week interactive, multi-component, multimedia online training that consists of instruction in specific self-management strategies, disease education, and social support. The content is rooted in cognitive-behavioral principles of disease self-management. In addition to the web-based modules, the intervention consists of monthly telephone support for 3 months by a trained bilingual health coach (research nurse) to review material and help enhance motivation.

Web-based coping skills training

The online disease education intervention provides access to an online resource center containing links to 12 educational websites about Juvenile Idiopathic Arthritis. Participants will be asked to review one educational website per week over the course of 12 weeks. Participants also will receive three monthly phone calls by a bilingual nurse "health coach" to discuss the participant's efforts at managing his/her disease.

Online disease education

Eligibility Criteria

Age12 Years - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • years of age (inclusive)
  • diagnosed with JIA by a pediatric rheumatologist
  • able to speak and read English and/or Spanish
  • able to complete online measures
  • reporting pain in at least one joint over the past 6 months

You may not qualify if:

  • have another chronic medical condition that adversely impacts pain and/or health-related quality of life (e.g., inflammatory bowel disease, fibromyalgia, cancer, genetic disorder, pervasive developmental disorder, diabetes)
  • have a significant cognitive impairment or illiteracy that would prevent understanding of the intervention and outcome measures
  • currently in psychotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (10)

University of California San Francisco Benioff Children's Hospital

San Francisco, California, 94143, United States

Location

Lurie Children's Hospital

Chicago, Illinois, 60614-3363, United States

Location

Riley Hospital for Children

Indianopolis, Indiana, 46202, United States

Location

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States

Location

Joseph M. Sanzari Children's Hospital

Hackensack, New Jersey, 07601, United States

Location

Duke University Medical Center

Durham, North Carolina, 27705, United States

Location

Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

Location

The Children's Hospital at Legacy Emmanuel Medical Center

Portland, Oregon, 97227, United States

Location

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723, United States

Location

Seattle Children's Hospital

Seattle, Washington, 98133, United States

Location

MeSH Terms

Conditions

Arthritis, Juvenile

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Mark Connelly, PhD (Principal Investigator)
Organization
Children's Mercy Hospital

Study Officials

  • Mark A Connelly, PhD

    Children's Mercy Hospital Kansas City

    PRINCIPAL INVESTIGATOR
  • Jennifer Stinson, PhD

    The Hospital for Sick Children

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 24, 2012

First Posted

March 1, 2012

Study Start

July 1, 2012

Primary Completion

April 1, 2016

Study Completion

June 1, 2016

Last Updated

March 9, 2017

Results First Posted

March 9, 2017

Record last verified: 2017-01

Data Sharing

IPD Sharing
Will share

A deidentified dataset is available for secondary analyses per our Resource Sharing Plan.

Locations