NCT01541566

Brief Summary

The purpose of this study is to assess whether, in patients at high cardiovascular risk (hypertension with metabolic syndrome), long-term (1-year) blood pressure control is most effective when based on home blood pressure telemonitoring and on the feedback to the patient by the doctor between visits, or when based only on blood pressure determination during quarterly office visits.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
254

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2007

Typical duration for all trials

Geographic Reach
1 country

12 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2007

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2010

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

February 17, 2012

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 1, 2012

Completed
Last Updated

February 26, 2016

Status Verified

February 1, 2016

Enrollment Period

3.1 years

First QC Date

February 17, 2012

Last Update Submit

February 25, 2016

Conditions

Keywords

arterial hypertensionmetabolic syndromehome blood pressureambulatory blood pressureoffice blood pressuretelemedicine

Outcome Measures

Primary Outcomes (2)

  • Percentage of subjects with average day-time ambulatory blood pressure <135/85 mmHg

    6 months

  • Percentage of subjects with average day-time ambulatory blood pressure <135/85 mmHg

    12 months

Secondary Outcomes (26)

  • Psychological determinats of therapeutic adherence

    6 months

  • Percentage of subjects with office blood pressure <140/90 mmHg

    6 months

  • Changes in home blood pressure

    6 months

  • Number of additional medical visits

    6 months

  • Direct costs of intervention

    6 months

  • +21 more secondary outcomes

Study Arms (2)

Home blood pressure telemonitoring

Patients regularly monitoring their blood pressure at home with an electronic validated upper arm device, transmitting blood pressure values at monthly intervals to the doctors office through the Internet.

Conventional blood pressure measurement

Blood pressure measured only in the doctor's office during quarterly visits, without regular home blood pressure monitoring.

Eligibility Criteria

Age18 Years - 74 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients referring to 12 Hypertension Centers (Hospitals) and suffering from arterial hypertension associated to metabolic syndrome

You may qualify if:

  • Treated or untreated uncontrolled essential arterial hypertension (office systolic blood pressure \>140 or diastolic \>90 mmHg + day-time systolic blood pressure \>135 or day-time diastolic blood pressure \>85 mmHg)
  • Metabolic syndrome (ATP III criteria)

You may not qualify if:

  • Secondary arterial hypertension
  • Severe liver or kidney disease
  • Immunological disease
  • Cardiac arrhythmias

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (12)

Policlinico Universitario

Bari, Bari, 70124, Italy

Location

Spedali Civili

Brescia, Brescia, 25123, Italy

Location

Fondazione Maugeri

Lumezzane, Brescia, 25066, Italy

Location

Ospedale San Felice a Cancello

San Felice A Cancello, Caserta, 81027, Italy

Location

Istituto Auxologico Italiano

Milan, Milano, 20149, Italy

Location

Policlinico Universitario

Padua, Padova, 35128, Italy

Location

Ospedale di Broni

Broni, Pavia, 27043, Italy

Location

Fondazione Maugeri

Pavia, Pavia, 27100, Italy

Location

Ospedale Santa Chiara

Pisa, Pisa, 56100, Italy

Location

Ospedale Fatebenefratelli

Roma, Roma, 00186, Italy

Location

Casa di Cura Tortorella

Salerno, Salerno, 84122, Italy

Location

Ospedale di Circolo

Varese, Varese, 21100, Italy

Location

Related Publications (2)

  • Brugnera A, Compare A, Omboni S, Greco A, Carrara S, Tasca GA, Poletti B, Parati G. Psychological covariates of blood pressure among patients with hypertension and metabolic syndrome. Health Psychol. 2022 Dec;41(12):946-954. doi: 10.1037/hea0001205. Epub 2022 Jul 21.

  • Parati G, Omboni S, Compare A, Grossi E, Callus E, Venco A, Destro M, Villa G, Palatini P, Rosei EA, Scalvini S, Taddei S, Manfellotto D, Favale S, De Matteis C, Guglielmi M; TELEBPMET Study Group; Lonati L, Della Rosa F, Tosazzi E, Grandi AM, Maresca AM, Mongiardi C, Mare M, Ricci AR, Cagnoni F, Georgatos J, Besostri V, Ferrari V, Omodeo O, Dorigatti F, Bonso E, Guarnieri C, Muiesan L, Paini A, Stassaldi D, Cinelli A, Bernocchi P, Rocchi S, Magagna A, Ghiadoni L, Del Frate I, Boresi F, Guidi A, Re MA, Pellicciotti L, Florio A, Morani G, Di Lillo S, Ambrosio A, Casciello A, Quaglia M, Forleo C, Ardito MA, Gerunda S, Panunzio M. Blood pressure control and treatment adherence in hypertensive patients with metabolic syndrome: protocol of a randomized controlled study based on home blood pressure telemonitoring vs. conventional management and assessment of psychological determinants of adherence (TELEBPMET Study). Trials. 2013 Jan 23;14:22. doi: 10.1186/1745-6215-14-22.

MeSH Terms

Conditions

HypertensionMetabolic Syndrome

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesInsulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Gianfranco Parati, MD

    Istituto Auxologico Italiano

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 17, 2012

First Posted

March 1, 2012

Study Start

November 1, 2007

Primary Completion

December 1, 2010

Study Completion

December 1, 2010

Last Updated

February 26, 2016

Record last verified: 2016-02

Locations