Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information

NCT01537224 | Completed

• 1 other identifier: 2011-A00392-39
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals. Deep brain stimulation surgery provides an opportunity to study these structures in humans in electrophysiological terms. The aim of this study is to investigate modifications in the electrophysiological activity of the subthalamic nucleus (STN) during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson's disease who have just undergone implantation of a deep brain stimulator in the STN.

Conditions

Parkinson

Keywords

Electrophysiology; Subthalamic nucleus; Parkinson

Outcome Measures

Primary Outcomes (1)

• Electrophysiological activity of the subthalamic nucleus

  Electrophysiological activity of the subthalamic nucleus will be measured during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson disease who have just undergone implatation of a deep brain stimulator in the subthalamic nucleus

  5 days

Study Arms (1)

neurostimulation

OTHER

Other: Measure of the electrophysiological activity of the subthalamic nucleus

Interventions

Measure of the electrophysiological activity of the subthalamic nucleus OTHER

Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.

neurostimulation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient with Parkinson's disease selected for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in accordance with the criteria established by Welter and colleagues (Welter et al., 2002);
• Aged 18 years or above;
• Written informed consent from the patient.

You may not qualify if:

• Patient under a legal incapacity or with limited legal capacity;
• Patient who has perioperative complications or postoperative confusion;
• Patient displaying cognitive disturbances involving the early stages of speech processing (on the basis of an audiogram systematically conducted prior to surgery) ;
• Patient displaying cognitive disturbances involving the early stages of face processing (on the basis of the Benton Facial Recognition Test (Benton, Hamsher, Varney, \& Spreen, 1983) systematically administered prior to surgery);
• Patient incapable of understanding the information given about the study, performing the tasks or providing informed consent.

Sponsors & Collaborators

• Rennes University Hospital: lead

Study Sites (1)

CHU Rennes

Rennes, 35000, France

Location

Study Officials

• Marc Verin, MD, PhD

  Rennes University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2012
• First Posted: February 23, 2012
• Study Start: September 12, 2011
• Primary Completion: November 26, 2015
• Study Completion: October 1, 2016
• Last Updated: June 15, 2026

Record last verified: 2026-06

Locations

FR (1)