3D Breast Ultrasound Elastography in Patients Under Neoadjuvant Chemotherapy
Imagerie 3D d'élasticité du Sein Par échographie Ultrarapide au Cours d'un Traitement Par chimiothérapie néoadjuvante.
2 other identifiers
interventional
33
1 country
1
Brief Summary
Breast Ultrasound Elastography is a complementary technique permitting a better characterization of breast lesions. 3D breast ultrasound elastography is a novel technique permitting a volumetric calculation of lesion stiffness. This could be particularly useful in patients with large breast tumors under pre-operative chemotherapy
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Dec 2010
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
February 8, 2012
CompletedFirst Posted
Study publicly available on registry
February 10, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedAugust 27, 2025
February 1, 2016
1.9 years
February 8, 2012
August 26, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
3D volumetric elasticity measurements
An utrafast shear wave imaging 3-plane acquisition provides several frames of breast lesion elasticity, that are reconstructed by means of a dedicated software thus permitting the direct volumetric elasticity measurements in kPa
10min
Study Arms (1)
shear wave imaging
EXPERIMENTALSingle arm study evaluating breast 3D elastography by means of shear wave propagation into breast tissue.
Interventions
Aixplorer Supersonic Imagine Ultrasound System with 3D probe for real-time elastography
Eligibility Criteria
You may qualify if:
- Patients having already undergone a breast MRI
- Patients presenting with breast lesions measuring between20-50mm in ultrasound
You may not qualify if:
- Multifocal lesions
- History of breast cancer
- Breast implants
- Inflammatory breast disease
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Curie Cancer Institute
Paris, 75005, France
Related Publications (2)
Athanasiou A, Latorre-Ossa H, Criton A, Tardivon A, Gennisson JL, Tanter M. Feasibility of Imaging and Treatment Monitoring of Breast Lesions with Three-Dimensional Shear Wave Elastography. Ultraschall Med. 2017 Jan;38(1):51-59. doi: 10.1055/s-0034-1398980. Epub 2015 Mar 5.
PMID: 25741668BACKGROUNDAthanasiou A, Tardivon A, Tanter M, Sigal-Zafrani B, Bercoff J, Deffieux T, Gennisson JL, Fink M, Neuenschwander S. Breast lesions: quantitative elastography with supersonic shear imaging--preliminary results. Radiology. 2010 Jul;256(1):297-303. doi: 10.1148/radiol.10090385. Epub 2010 May 26.
PMID: 20505064BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Alexandra Athanasiou, MD
Curie Cancer Institute
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 8, 2012
First Posted
February 10, 2012
Study Start
December 1, 2010
Primary Completion
November 1, 2012
Study Completion
November 1, 2012
Last Updated
August 27, 2025
Record last verified: 2016-02