Cost of Illness Associated With Influenza in the UK

NCT01521416 | Completed

• 1 other identifier: 116313
• Study Type: observational
• Target: 1
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this study is to describe the burden associated with influenza in the UK, from both primary and secondary care perspectives, and to stratify the burden by the annual degree of mismatch between predicted and actual virus strains.

Conditions

Influenza

Keywords

Illness; Influenza; Cost; UK

Outcome Measures

Primary Outcomes (7)

• Incidence of influenza-related events

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Number of confirmed influenza infections

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Assessment of resource use

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Evaluation of patient outcomes, treatments and costs (type and duration)

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Cause of deaths

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Incidence of influenza-related events in High Risk groups

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

• Incidence of complications and exacerbations

  Over the study time period (from January 21st 2001 to March 31st 2009 inclusive)

Study Arms (1)

Cohort Group

Other: Data collection

Interventions

Data collection OTHER

Data of patients diagnosed with acute respiratory illness is extracted from General Practice Research Database (GPRD), Hospital Episode Statistics (HES), the Health Protection Agency (HPA), Office of National Statistics (ONS), and National Health Service (NHS) Reference Costs, during the period January 21st 2001 and March 31st 2009 inclusive. All analyses of primary care data (GPRD) and separately for secondary care (HES) data will be repeated for all eligible patients, and the subset of patients with a linkage to additional data (HES, ONS). All analysis including secondary care data will be restricted to the subset of patients with linked HES data. Estimates of average burden per patient and total burden in the UK will be performed. Burden is defined as both resource use and cost. Annual incidence and burden will be calculated.

Cohort Group

Eligibility Criteria

• Age: 5 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients coded within the relevant database (GPRD and HES) as having acute respiratory events that could be related to an infection between 2001 and 2009.

You may qualify if:

• Male or female patients coded within the database as having acute respiratory events that could be related to an infection between 2001 and 2009.
• Patients must have a minimum of 14 days observation before and after the index event to permit the capturing of complications attributable to influenza.

You may not qualify if:

• Not Applicable

Sponsors & Collaborators

• GlaxoSmithKline: lead

MeSH Terms

Conditions

Influenza, Human

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• GSK Clinical Trials

  GlaxoSmithKline

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2012
• First Posted: January 30, 2012
• Study Start: June 1, 2011
• Primary Completion: April 1, 2013
• Study Completion: April 1, 2013
• Last Updated: September 2, 2013

Record last verified: 2013-08