NCT01520064

Brief Summary

  • Obtain and analyze medical record data on patients with advanced emphysema who receive treatment with the AeriSeal System to better understand safety and effectiveness in the post-market setting;
  • Provide participating physicians access to specified data sets for the purpose of generating scientific manuscripts about the effects of AeriSeal System treatment.

Trial Health

60
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Feb 2012

Geographic Reach
2 countries

12 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 25, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 27, 2012

Completed
5 days until next milestone

Study Start

First participant enrolled

February 1, 2012

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2013

Completed
Last Updated

November 14, 2013

Status Verified

November 1, 2013

Enrollment Period

1.8 years

First QC Date

January 25, 2012

Last Update Submit

November 13, 2013

Conditions

Keywords

EmphysemaGOLD Stage IIIGOLD Stage IVAeriSeal SystemHomogeneousHeterogeneousUpper Lobe PredominantULPChronic Obstructive Pulmonary DiseaseCOPDLung Volume Reduction SurgeryLVRSBronchoscopic Lung Volume ReductionBLVR

Outcome Measures

Primary Outcomes (1)

  • Post Market Registry Study of the AeriSeal System

    -Obtain and analyze medical record data on patients with advanced emphysema who receive treatment with the AeriSeal System to better understand safety and effectiveness in the post-martet setting

    At least 4 years

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients must have been or will be treated with the AeriSeal System

You may qualify if:

  • Advanced Emphysema
  • AeriSeal System treatment

You may not qualify if:

  • have a primary diagnosis of asthma, chronic bronchitis or bronchiectasis
  • have had frequent COPD exacerbations within the past year
  • require mechanical ventilatory support
  • have a pretreatment DLCO \< 20% predicted or \> 60% predicted
  • have a pretreatment FEV1 \< 20% predicted AND homogeneous emphysema
  • have giant bullae
  • have undergone lung transplantation, lung volume reduction surgery, or lobectomy
  • are intolerant of corticosteroids or antibiotics
  • are pregnant or breast-feeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (12)

Zentralklinik Bad Berka GmbH

Bad Berka, 99437, Germany

Location

Klinikum Coburg

Coburg, 96450, Germany

Location

Klinikum Donaustauf

Donaustauf, 93093, Germany

Location

Asklepios Fachkliniken Muenchen-Gauting

Gauting, 82131, Germany

Location

Universitatsklinikum Halle

Halle, 06120, Germany

Location

Asklepios Klinik Hamburg-Harburg

Hamburg, 21075, Germany

Location

Thoraxklinik am Uniklinikum Heidelberg

Heidelberg, D-69126, Germany

Location

Sana Kliniken Luebeck

Lübeck, 23560, Germany

Location

Klinikum Nuerberg Nord

Nuremberg, 90419, Germany

Location

Bethanien KH Solingen

Solingen, 42699, Germany

Location

Soroka Medical Center

Beer Sheeva, 84101, Israel

Location

Rabin Medical Center, Beilinson Campus

Petach Tikvah, 49100, Israel

Location

MeSH Terms

Conditions

Pulmonary EmphysemaEmphysemaPulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Janine McDermott, MS CCRP

    Aeris Therapeutics

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 25, 2012

First Posted

January 27, 2012

Study Start

February 1, 2012

Primary Completion

November 1, 2013

Study Completion

November 1, 2013

Last Updated

November 14, 2013

Record last verified: 2013-11

Locations