Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease

NCT01515709 | Completed

• 1 other identifier: 2011LF001H
• Study Type: observational
• Target: 445
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with Chronic Obstructive Lung Disease (COPD) often develop muscle problems, particularly in their legs which makes them more limited in what they can do. The Short Physical Performance Battery (SPPB) is a simple test of standing balance, usual walking speed and ability to stand from a chair. The SPPB may be a useful measure to predict leg function. This study aims to evaluate whether the SPPB is comparable with current exercise tests used in COPD patients, and whether it is useful in predicting disability, death and health resource usage over time.

Conditions

Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive; Pulmonary Emphysema; Bronchitis, Chronic; Lung Diseases; Disease Progression

Keywords

Cohort Studies; Longitudinal Studies

Outcome Measures

Primary Outcomes (1)

• Mortality rate

  36 months

Secondary Outcomes (2)

• Hospitalisation rate

  36 months

• Healthcare resource usage

  36 months

Study Arms (1)

Chronic Obstructive Pulmonary Disease

Patients with a diagnosis of COPD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Any patient with a diagnosis of COPD.

You may qualify if:

• Diagnosis of COPD

You may not qualify if:

• Any patient in whom mobility and lower limb function have been significantly affected by a neuromuscular cause (eg. motor neurone disease), severe peripheral vascular disease or amputation
• Any patient whom is deemed unsafe to exercise
• Patients unable to complete the SPPB, walking tests and leg strength assessments.

Sponsors & Collaborators

• Royal Brompton & Harefield NHS Foundation Trust: lead
• Medical Research Council: collaborator

Study Sites (1)

Harefield Hospital

Harefield, UB9 6JH, United Kingdom

Location

Related Publications (3)

• Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995 Mar 2;332(9):556-61. doi: 10.1056/NEJM199503023320902.

  PMID: 7838189 BACKGROUND

• Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994 Mar;49(2):M85-94. doi: 10.1093/geronj/49.2.m85.

  PMID: 8126356 BACKGROUND

• Nolan CM, Kon SSC, Patel S, Jones SE, Barker RE, Polkey MI, Maddocks M, Man WD. Gait speed and pedestrian crossings in COPD. Thorax. 2018 Feb;73(2):191-192. doi: 10.1136/thoraxjnl-2017-210173. Epub 2017 May 5.

  PMID: 28476882 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive; Pulmonary Emphysema; Bronchitis, Chronic; Lung Diseases; Disease Progression

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases

Study Officials

• William DC Man, MRCP PhD

  NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2012
• First Posted: January 24, 2012
• Study Start: April 1, 2011
• Primary Completion: September 1, 2013
• Study Completion: September 1, 2018
• Last Updated: October 3, 2018

Record last verified: 2018-10

Locations

GB (1)