Time-lapse Evaluation of Human Embryo Development in Single Versus Sequential Culture Media - a Sibling Oocyte Study

NCT01507883 | Unknown

• 1 other identifier: BHC1
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Current human IVF technology employs two strategies with respective culture media for embryo development; 'let the embryo choose' (utilizes single step media) and 'back-to-nature' (utilizes sequential media). To our knowledge, there is not any sibling oocyte study to evaluate potential advantages/disadvantages of these strategies on one another.

Conditions

In-vitro Fertilization

Keywords

Supervision; embryos; Resulting

Study Arms (1)

human oocytes/embryos

Sibling oocytes cultured in single or sequential media until day6

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Women who had undergone infertility treatment and oocytes subjected to ICSI

You may qualify if:

• Cycles which have gone through egg retrieval procedure between March to November 2011 were included into the study.There was no restriction on the number of previous trials and/or sperm source.

You may not qualify if:

• The maximum number of retrieved oocytes was restricted to 12 and the minimum to 2, as the former was the capacity of one dish (EmbryoSlide™) in which oocytes/embryos could be placed and the latter was the minimum number to be able to make a comparison between groups. Women who were older than 40 years of age were excluded in order to minimize the impact of increased risk of aneuploidy on the results.
• Cycles in which oocytes/embryos have been subjected to biopsy were also excluded due to the potential risk of delayed embryo development in such cases (Kirkegaard et al., 2011).
• Furthermore, cycles in which diagnosis of infertility was endometrial factor were not included since such aetiology could negatively affect implantation despite good embryo development.

Sponsors & Collaborators

• Bahceci Health Group: lead

Study Sites (1)

Bahceci Fulya IVF Clinic

Istanbul, Turkey (Türkiye)

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Human embryos

Study Officials

• Nadir H Ciray, MD., PhD

  Bahceci Health Group

  PRINCIPAL INVESTIGATOR

• Turan Aksoy, BS

  Bahceci Health Group

  STUDY CHAIR

• Mustafa Bahceci, MD

  Bahceci Health Group

  STUDY DIRECTOR

• Cihan Goktas, BS

  Bahceci Health Group

  STUDY CHAIR

• Birgen Ozturk, BS

  Bahceci Health Group

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, MD., PhD

Study Record Dates

• First Submitted: January 9, 2012
• First Posted: January 11, 2012
• Study Start: March 1, 2011
• Primary Completion: December 1, 2011
• Study Completion: January 1, 2012
• Last Updated: January 11, 2012

Record last verified: 2012-01

Locations

TU (1)