Assessment of Airways Mechanical Properties by FOT and LIR During Anesthesia

NCT01506284 | Completed

• 1 other identifier: Uppsala 2011 - 189
• Study Type: observational
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The aims of the present study are:

1. 1.To evaluate the effect of the induction of anaesthesia and paralysis in terms of changes in oscillatory mechanics parameters
2. 2.To evaluate the mechanical properties of the respiratory system in terms of input and transfer oscillatory impedance in response to PEEP changes

Conditions

Anesthesia

Keywords

Forced oscillatory technique; Laser interferometry; Intravenous anesthesia; Mechanical ventilation; Pressure controlled ventilation; Airways mechanical properties; Respiratory system reactance; Oscillatory mechanics; Atelectasis

Outcome Measures

Primary Outcomes (1)

• Change in respiratory system impedance

  FOT measurements: Respiratory system impedance will be computed from the flow and pressure signals measured at the inlet of the tracheal tube. A composite waveform including 5, 11 and 19 Hz will be used as a stimulating signal generated by an A/D-D/A board and amplified by a power amplifier that drives a loudspeaker the output of which is connected to inspiratory line of the ventilator.

  baseline and 5 minutes of ventilation

Secondary Outcomes (3)

• Change in chest wall displacement measured by LIR

  baseline and 5 minutes of ventilation

• Change in oxygenation (paO2)

  baseline and 5 minutes of ventilation

• Change in Functional residual capacity (FRC)

  baseline and 5 minutes of ventilation

Study Arms (1)

Anesthetized patients ASA I-II

ASA classification I-II, scheduled for elective surgery requiring general anesthesia.

Procedure: Forced oscillatory technique (FOT) and laser interferometry (LIR).

Interventions

Forced oscillatory technique (FOT) and laser interferometry (LIR). PROCEDURE

FOT: The stimulating signal is generated by an A/D-D/A board and amplified by a power amplifier that drives a loudspeaker the output of which is connected to inspiratory line of the ventilator. Pressure and flow are measured at the inlet of the endotracheal tube by a piezoresistive pressure transducer and a mesh-type heated pneumotachograph coupled with a differential pressure transducer. LIR: The scanner unit is made by three laser interferometers, the beams of which are deflected on the chest wall surface by a mirror moved by a stepper motor triggered on the respiratory pattern of patient.

Anesthetized patients ASA I-II

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients ASA classification I-II, scheduled for elective surgery requiring general anesthesia

You may qualify if:

• age \>18 years
• ASA I-II, scheduled for elective surgery requiring general anesthesia
• signed informed consent

You may not qualify if:

• patient refusal
• BMI \> 35
• co-existing respiratory disease (COPD, asthma, restrictive lung disease)
• pregnancy

Sponsors & Collaborators

• Uppsala University Hospital: lead
• Politecnico di Milano: collaborator

Study Sites (1)

Uppsala University Hopsital, Dep. of Anesthesia and Intensive Care

Uppsala, Uppsala County, 751 85, Sweden

Location

Related Publications (3)

• Dellaca RL, Andersson Olerud M, Zannin E, Kostic P, Pompilio PP, Hedenstierna G, Pedotti A, Frykholm P. Lung recruitment assessed by total respiratory system input reactance. Intensive Care Med. 2009 Dec;35(12):2164-72. doi: 10.1007/s00134-009-1673-3. Epub 2009 Sep 30.

  PMID: 19789855 BACKGROUND

• Dellaca RL, Zannin E, Kostic P, Olerud MA, Pompilio PP, Hedenstierna G, Pedotti A, Frykholm P. Optimisation of positive end-expiratory pressure by forced oscillation technique in a lavage model of acute lung injury. Intensive Care Med. 2011 Jun;37(6):1021-30. doi: 10.1007/s00134-011-2211-7. Epub 2011 Apr 1.

  PMID: 21455750 BACKGROUND

• Kostic P, Zannin E, Andersson Olerud M, Pompilio PP, Hedenstierna G, Pedotti A, Larsson A, Frykholm P, Dellaca RL. Positive end-expiratory pressure optimization with forced oscillation technique reduces ventilator induced lung injury: a controlled experimental study in pigs with saline lavage lung injury. Crit Care. 2011;15(3):R126. doi: 10.1186/cc10236. Epub 2011 Apr 28.

  PMID: 21575220 BACKGROUND

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Peter Frykholm, MD, PhD

  Uppsala University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 9, 2011
• First Posted: January 9, 2012
• Study Start: November 1, 2011
• Primary Completion: March 1, 2012
• Study Completion: November 1, 2012
• Last Updated: December 9, 2014

Record last verified: 2012-01

Locations

SE (1)