NCT01503645

Brief Summary

  1. 1.Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).
  2. 2.AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer
  3. 3.Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.
  4. 4.By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Trial Health

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Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2006

Completed
5.7 years until next milestone

First Submitted

Initial submission to the registry

January 2, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 4, 2012

Completed
Last Updated

November 14, 2012

Status Verified

January 1, 2012

First QC Date

January 2, 2012

Last Update Submit

November 12, 2012

Conditions

Kidney Diseases

Keywords

kidney diseasesdrugs, Chinese herbalaristolochic acidpolymorphism, genetic

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

People who use Chinese herb

You may qualify if:

  • Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Far Estern Memorial Hospital

Banqiao District, Taipei, 22060, Taiwan

NOT YET RECRUITING

National Taiwan University Hospital

Taipei, 10051, Taiwan

RECRUITING

MeSH Terms

Conditions

Kidney Diseases

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Kwan-Dun Wu, MD, PhD

    National Taiwan University Hospital

    STUDY CHAIR

Central Study Contacts

Fe-Lin L Wu, Ph.D.

CONTACT

+886-2-23938231flwu@ha.mc.ntu.edu.tw

Kwan-Dun Wu, MD, Ph.D.

CONTACT

+886-2-23123456kdw@ntumc.org

Study Design

Study Type
observational
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 2, 2012

First Posted

January 4, 2012

Study Start

May 1, 2006

Last Updated

November 14, 2012

Record last verified: 2012-01

Locations

TW(2)