Effect of Transmagnetic Stimulation on Conditioned Pain Modulation (CPM)
The Effect of Transmagnetic Stimulation on Descending Pain Modulation
1 other identifier
interventional
94
1 country
1
Brief Summary
While some indications of the neural circuits involved in the Conditioned Pain Modulation (CPM) process are now available, there is still need to clarify what parts of the brain are essential for this process, whether the spino-brainstem loop is largely sufficient to explain CPM or whether other cerebral and spinal regions such as frontal, somatosensory and other cortical regions contribute substantially. Whereas mere observation of correlation between these circuits while activated by brain imaging is still of considerable interest, direct experimental manipulations by repetitive transcranial magnetic stimulation (rTMS) could even establish insights into causal relationships.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2011
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedFirst Submitted
Initial submission to the registry
December 12, 2011
CompletedFirst Posted
Study publicly available on registry
December 29, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 6, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
November 6, 2017
CompletedMarch 27, 2019
March 1, 2019
6.9 years
December 12, 2011
March 26, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Pain scores as measured by pain numerical scale (NPS)
TMS directed to pain inhibitory cortical areas will evoke pain reduction
1 week
Amplitude of pain-evoked potentials
Change in pain evoked potentials will be assessed before and after the TMS
1 week
Secondary Outcomes (1)
conditioned pain modulation (CPM)
1 week
Study Arms (2)
healthy subjects
EXPERIMENTALhealthy subjects
pain patients
EXPERIMENTALMigraine and muscle headache patients
Interventions
repeated TMS (rTMS)
Eligibility Criteria
You may qualify if:
- age 18-70
- males and females
- right handed
You may not qualify if:
- metal in brain/skull
- cardiac pacemaker
- cohlear implants
- history of head trauma
- history of epilepsy or seizures
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Rambam Health Care Campuslead
- German Research Foundationcollaborator
Study Sites (1)
The lab of clinical neurophysiology, the faculty of medicine, Technion and Rambam Medical Center
Haifa, Israel
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David Yarnitsky, professor
Rambam Health Care Campus
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- head of Neurology Department
Study Record Dates
First Submitted
December 12, 2011
First Posted
December 29, 2011
Study Start
January 1, 2011
Primary Completion
November 6, 2017
Study Completion
November 6, 2017
Last Updated
March 27, 2019
Record last verified: 2019-03