Noninvasive Study of Brain Connectivity With EEG and NIRS

NCT01493804 | Completed

• 2 other identifiers: 12001112-CH-0011
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- Different regions of the brain are activated when a person performs a task. Electroencephalograms (EEGs) and near-infrared spectroscopy (NIRS) are tests that detect changes in the brain. EEG looks at changes in electrical signals, and NIRS looks at changes in blood flow. These tests can detect local changes in brain activity in a safe and noninvasive way. Researchers want to study brain activity more closely by combining these tests. Objectives: \- To use EEG and NIRS to study brain activity during specific tasks. Eligibility: \- Healthy volunteers at least 18 years of age. Design:

• Participants will be screened with a physical exam and medical history.
• Participants will have between one and five testing sessions. Each session will be 1 to 2 hours long. The tests given at each session will be determined by the researchers.
• Participants will have EEG and NIRS tests, given either separately or together. During these tests, participants will perform tasks of thinking and reasoning.
• Participants may also complete optional tests of thinking and reasoning. These tests will be given on paper or on a computer.

Conditions

Healthy Volunteers

Keywords

Near Infrared Spectroscopy; EEG; Brain Connectivity; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or greater.

You may not qualify if:

• Healthy volunteers with any skin disease.
• Past or present hematologic abnormality of Hgb \< 9.0 gm/dl.
• Healthy volunteers with any past or present vascular disease.
• Have a history of substance abuse, psychiatric, or neurological disorders
• Unable or unwilling to give informed consent.

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Akgul CB, Akin A, Sankur B. Extraction of cognitive activity-related waveforms from functional near-infrared spectroscopy signals. Med Biol Eng Comput. 2006 Nov;44(11):945-58. doi: 10.1007/s11517-006-0116-3. Epub 2006 Oct 24.

  PMID: 17061116 BACKGROUND

• Aydore S, Mihcak MK, Ciftci K, Akin A. On temporal connectivity of PFC via Gauss-Markov modeling of fNIRS signals. IEEE Trans Biomed Eng. 2010 Mar;57(3):761-8. doi: 10.1109/TBME.2009.2020792. Epub 2009 Apr 28.

  PMID: 19403360 BACKGROUND

• Badre D, Wagner AD. Selection, integration, and conflict monitoring; assessing the nature and generality of prefrontal cognitive control mechanisms. Neuron. 2004 Feb 5;41(3):473-87. doi: 10.1016/s0896-6273(03)00851-1.

  PMID: 14766185 BACKGROUND

Study Officials

• Amir Gandjbakhche, Ph.D.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2011
• First Posted: December 16, 2011
• Study Start: November 8, 2011
• Study Completion: September 1, 2017
• Last Updated: September 6, 2017

Record last verified: 2017-09-01

Locations

US (1)