Functional Imaging of Psychic Pain

NCT01493323 | Terminated

• 1 other identifier: UF 8555
• Study Type: interventional
• Target: 123
• Locations: 1 country
• Sites: 1

Brief Summary

Suicidal behaviour (SB) represents a major public health problem, costing life in more that one million people every year worldwide. Even if SB is considered as a consequence of social adversity and depression, these stress factors are often necessary but not sufficient to explain the occurrence of a suicidal act. A preliminary study suggests that an increased perception of psychic pain during a major depressive disorder increases the risk of suicide behaviour. The investigators aimed to investigate the relationship between social exclusion (a classic trigger of psychic pain) and SB and improve our knowledge about the physiopathology of this domain.

Conditions

Suicide, Attempted; Mood Disorder

Keywords

Psychic pain; Social exclusion; Mood disorders; Suicide, attempted; Magnetic Resonance Imaging, Functional; Genetic; Physic pain

Outcome Measures

Primary Outcomes (2)

• Cerebral regions associated with psychic pain during a major depressive disorder

  Magnetic Resonance Imaging to visualize cerebral regions associated with psychic pain during a major depressive disorder

  One day

• Cerebral regions associated with perception of social exclusion

  Magnetic Resonance Imaging to visualize the cerebral regions associated with perception of social exclusion

  One day

Study Arms (2)

Control

EXPERIMENTAL

Behavioral: Assessment of personality traits; Behavioral: Assessment of suicidal act; Behavioral: Assessment of depression; Procedure: Cyber ball game; Procedure: Iowa Gambling Task; Procedure: Microcomputer; Procedure: blood sample

Depressive attempters

EXPERIMENTAL

Behavioral: Assessment of personality traits; Behavioral: Assessment of suicidal act; Behavioral: Assessment of depression; Procedure: Cyber ball game; Procedure: Iowa Gambling Task; Procedure: Microcomputer; Procedure: blood sample

Interventions

Assessment of personality traits BEHAVIORAL

suicide behaviour , psychic pain, social exclusion, decision making...

Also known as: impulsivity, anger, anxiety, emotional lability, self-administered questionnaires

Control; Depressive attempters

Assessment of suicidal act BEHAVIORAL

suicide behaviour , psychic pain, social exclusion, decision making...

Also known as: SIS, RRRS

Control; Depressive attempters

Assessment of depression BEHAVIORAL

suicide behaviour , psychic pain, social exclusion, decision making...

Also known as: BDI, HAMD-21

Control; Depressive attempters

Cyber ball game PROCEDURE

functional neuroimaging

Also known as: fIRM

Control; Depressive attempters

Iowa Gambling Task PROCEDURE

functional neuroimaging

Control; Depressive attempters

Microcomputer PROCEDURE

functional neuroimaging

Also known as: palm

Control; Depressive attempters

blood sample PROCEDURE

blood sample

Control; Depressive attempters

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Non specific criteria, for all the participants: * Woman- 18-50 years old * Non menopausal * Right-handed * Caucasian from western Europe (exception of Basque and Sardinian), for genetic purposes * Subject who signed informed consent * Able to understand the nature, the aim, and the methodology of the study and agree to cooperate during clinical and radiological evaluation Specific criteria:For depressed suicide attempters : * DSM IV criteria for major depressive disorder * Personal history of suicide attempt * No psychotropic treatment currently For depressed affective controls : * DSM IV criteria for major depressive disorder * No personal history of suicide attempt * No psychotropic treatment currently For non depressed suicide attempters : * Personal history of unipolar or bipolar mood disorder, according to DSM IV criteria * Normothymic currently (HAMD\<7) * Personal history of suicide attempt * Minimum treatment Healthy controls : * No personal history of axis I psychiatric disorders according to the MINI and the DSM IV criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• University Hospital, Geneva: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator

Study Sites (1)

MontpellierUniversity Hopital

Montpellier, 34000, France

Location

MeSH Terms

Conditions

Suicide, Attempted; Mood Disorders; Social Isolation

Interventions

mycophenolic adenine dinucleotide; PALM protein, human; Blood Specimen Collection

Condition Hierarchy (Ancestors)

Suicide; Self-Injurious Behavior; Behavioral Symptoms; Behavior; Mental Disorders; Social Behavior

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Philippe PC Courtet, Professor(MD-PhD)

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 10, 2011
• First Posted: December 15, 2011
• Study Start: May 1, 2010
• Primary Completion: August 1, 2014
• Study Completion: December 1, 2014
• Last Updated: December 4, 2014

Record last verified: 2014-12

Locations

FR (1)