Different Endurance Training Protocols in Cardiac Rehabilitation

NCT01493193 | Completed Phase 4

• 1 other identifier: UISM-5
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

It is the aim of the study to compare the effects of 6 weeks of either high-intensity interval training (HIT; carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients. The three exercise arms (isocaloric) are composed as follows: Endurance training (n=15): 31min at 65-75% HRmax; HIT (n=15): 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min; Pyramids (n=15): One Pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block at 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min. All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRpeak. Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate thresholds at 2 and 4 mmol/l.

Conditions

Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• Individual maximum power output in watt (Pmax)

  Change of individual maximum power output in watt (Pmax) on a bicycle ergometer after the training intervention of controlled physical activity within 6 weeks

  6 weeks

Secondary Outcomes (1)

• Power output in watt at lactate threshold of 2 and 4 mmol/l

  6 weeks

Study Arms (3)

Endurance training with constant work load

ACTIVE COMPARATOR

Other: Endurance training with constant work load

Pyramid-Training

EXPERIMENTAL

Other: Pyramid-Training

High-intensity interval training

EXPERIMENTAL

Other: High-intensity interval training

Interventions

Endurance training with constant work load OTHER

Endurance training with constant work load(n=15): 31min at 65-75% HRmax

Endurance training with constant work load

Pyramid-Training OTHER

Pyramid-Training (n=15): One Pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block at 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.

Pyramid-Training

High-intensity interval training OTHER

HIT (n=15): 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min

High-intensity interval training

Eligibility Criteria

• Age: 25 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least one of the following diagnoses within the previous 3 months:
• acute coronary syndrome (STEMI)
• acute coronary syndrome (NSTEMI)
• aortocoronary bypass surgery
• PCI
• stable coronary heart disease

You may not qualify if:

• Unstable angina pectoris
• Heart failure (NYHA IV)
• Acute endomyocarditis or other acute infections
• Pulmonary artery embolism or phlebothrombosis within the previous 6 months
• Hemodynamically unstable arrhythmia
• Hypertrophic cardiomyopathy
• participation in another study within the previous 6 months
• Medical conditions which prevent patients from complying with the exercise program

Sponsors & Collaborators

• Paracelsus Medical University: lead

Study Sites (1)

Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University

Salzburg, Salzburg, 5020, Austria

Location

Related Publications (5)

• Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP; HF-ACTION Investigators. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009 Apr 8;301(14):1451-9. doi: 10.1001/jama.2009.457.

  PMID: 19351942 BACKGROUND

• Niebauer J, Hambrecht R, Velich T, Hauer K, Marburger C, Kalberer B, Weiss C, von Hodenberg E, Schlierf G, Schuler G, Zimmermann R, Kubler W. Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise. Circulation. 1997 Oct 21;96(8):2534-41. doi: 10.1161/01.cir.96.8.2534.

  PMID: 9355890 BACKGROUND

• O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009 Apr 8;301(14):1439-50. doi: 10.1001/jama.2009.454.

  PMID: 19351941 BACKGROUND

• Helgerud J, Hoydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007 Apr;39(4):665-71. doi: 10.1249/mss.0b013e3180304570.

  PMID: 17414804 BACKGROUND

• Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. doi: 10.1161/CIRCULATIONAHA.106.675041. Epub 2007 Jun 4.

  PMID: 17548726 BACKGROUND

Related Links

• Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University Salzburg, Austria
• Salzburg Regional Hospital

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Endurance Training; High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Josef Niebauer, MD, PhD, MBA

  Paracelsus Medical University

  STUDY CHAIR

• Marcus Tschentscher, MSc

  Paracelsus Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Primar

Study Record Dates

• First Submitted: December 13, 2011
• First Posted: December 15, 2011
• Study Start: November 1, 2011
• Primary Completion: February 1, 2013
• Study Completion: May 1, 2013
• Last Updated: August 1, 2013

Record last verified: 2013-07

Locations

AU (1)