Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine
Effect of Tracheal Lidocaine on Intubating Conditions During Propofol-remifentanil TCI Without Neuromuscular Blockade
1 other identifier
interventional
50
1 country
1
Brief Summary
When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2011
CompletedFirst Submitted
Initial submission to the registry
December 7, 2011
CompletedFirst Posted
Study publicly available on registry
December 12, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2012
CompletedJuly 16, 2012
July 1, 2012
11 months
December 7, 2011
July 13, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Overall acceptable conditions for tracheal intubation
Four minutes after start of propofol-remifentanil TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, and one minute later, intubation was performed in double-blinded fashion.
baseline from 5 min of TCI was maintained
Study Arms (2)
control
EXPERIMENTAL3 ml of normal saline was instilled to larynx and trachea
lidocaine
ACTIVE COMPARATOR3 ml of 4% lidocaine was instilled to larynx and trachea before endotracheal intubation
Interventions
3 ml of 4% lidocaine was instilled to larynx and trachea
3 ml of normal saline was instilled to larynx and trachea before endotracheal intubation
Eligibility Criteria
You may qualify if:
- ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture
You may not qualify if:
- bronchial asthma,
- COPD,
- hypertension,
- anticipated difficult airway
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ajou University School of Medicine
Suwon, 443-721, South Korea
Related Publications (1)
Bulow K, Nielsen TG, Lund J. The effect of topical lignocaine on intubating conditions after propofol-alfentanil induction. Acta Anaesthesiol Scand. 1996 Jul;40(6):752-6. doi: 10.1111/j.1399-6576.1996.tb04523.x.
PMID: 8836274BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jong Yeop Kim, MD
Ajou University School of Medicine
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
December 7, 2011
First Posted
December 12, 2011
Study Start
May 1, 2011
Primary Completion
April 1, 2012
Study Completion
May 1, 2012
Last Updated
July 16, 2012
Record last verified: 2012-07