Neural Correlates of Stress Reduction
Structural and Functional Mechanisms of Stress Reduction
1 other identifier
interventional
140
1 country
1
Brief Summary
This study will identify neural mechanisms associated with changes in emotion regulation following participation in stress reduction programs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Dec 2011
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
December 5, 2011
CompletedFirst Posted
Study publicly available on registry
December 8, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2014
CompletedJanuary 15, 2015
January 1, 2015
3 years
December 5, 2011
January 14, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in gray matter structure
Study participants will undergo an MRI scan before and after attending an 8-week stress reduction program.
8 weeks
Secondary Outcomes (1)
Emotion regulation
8-weeks
Study Arms (2)
Group 1
ACTIVE COMPARATORBoth groups will receive stress reduction materials. We expect both groups to achieve similar amounts of stress reduction, but to use different brain regions to do so.
Group 2
ACTIVE COMPARATORBoth groups will receive stress reduction materials. We expect both groups to achieve similar amounts of stress reduction, but to use different brain regions to do so.
Interventions
We are comparing 2 well-studied approaches to stress reduction. All participants will receive stress reduction instructions that have already been proven to effectively reduce stress. Our goal is to compare the neural mechanisms associated with both approaches.
Eligibility Criteria
You may qualify if:
- years of age
- Right-handed
- Stressed
You may not qualify if:
- Lifetime history of schizophrenia or psychosis
- Psychiatric illness
- History of seizure or significant head trauma
- Use of psychotropic medications
- Metallic implants or devices contraindicating magnetic resonance imaging
- Claustrophobia
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Massachusetts General Hospital
Boston, Massachusetts, 02115, United States
Related Publications (1)
Sevinc G, Holzel BK, Greenberg J, Gard T, Brunsch V, Hashmi JA, Vangel M, Orr SP, Milad MR, Lazar SW. Strengthened Hippocampal Circuits Underlie Enhanced Retrieval of Extinguished Fear Memories Following Mindfulness Training. Biol Psychiatry. 2019 Nov 1;86(9):693-702. doi: 10.1016/j.biopsych.2019.05.017. Epub 2019 May 30.
PMID: 31303261DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sara Lazar, PhD
Massachusetts General Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Research Scientist
Study Record Dates
First Submitted
December 5, 2011
First Posted
December 8, 2011
Study Start
December 1, 2011
Primary Completion
December 1, 2014
Study Completion
December 1, 2014
Last Updated
January 15, 2015
Record last verified: 2015-01