Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Psychotic Patients

NCT01487291 | Completed DMC

• 1 other identifier: UFRiodJaneiro
• Study Type: observational
• Target: 176
• Locations: 1 country
• Sites: 1

Brief Summary

At the Thrombophilia Clinic of the Hospital Federal dos Servidores do Estado do Rio de Janeiro there is a high prevalence of acute psychotic episodes, which allows the investigators to raise the suspicion that the thrombotic tendency or hypofibrinolysis play a role in the onset of the disease. It is striking that most of these patients, after some time on anticoagulants, no longer need to take psychiatric medication.

Conditions

Insulin Resistance; Thrombophilia; Psychosis

Keywords

Thrombophilia tests; Hypofibrinolysis; Fibrinolysis

Outcome Measures

Primary Outcomes (1)

• Prevalence of hypofibrinolysis markers in psychotic patients

  The investigators' hypothesis is that a high prevalence of hypofibrinolysis markers will be probably found in psychotic patients.

  One year

Secondary Outcomes (1)

• Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Patients who Need Electroconvulsive Therapy

  2013-2014

Study Arms (1)

Psychotic patients

Inpatients and outpatients followed at Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, Brazil

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Psychotic patients treated at IPUB-UFRJ, comprising patients with schizophrenia, schizoaffective disorders, bipolar disorders (mania or depressive episodes, provided that the patient has shown an acute psychotic episode in the last two years. Age-matched control group

You may qualify if:

• Diagnosis of schizophrenia or schizoaffective disorder by the Semi-structured Interview MINI 5.0.

You may not qualify if:

• Inability to provide information.
• Use of illicit drugs.
• Infections such as cerebral toxoplasmosis in HIV seropositive or tertiary syphilis. Patients with "recurrent syphilis" will not be excluded, because false positive tests are common in antiphospholipid antibody syndrome.

Sponsors & Collaborators

• Universidade Federal do Rio de Janeiro: lead
• Rio de Janeiro State Research Supporting Foundation (FAPERJ): collaborator

Study Sites (1)

Institudo de Psiquiatria da UFRJ

Rio de Janeiro, Rio de Janeiro, 22290-140, Brazil

Location

Related Publications (3)

• Hoirisch-Clapauch S, Nardi AE. Multiple roles of tissue plasminogen activator in schizophrenia pathophysiology. Semin Thromb Hemost. 2013 Nov;39(8):950-4. doi: 10.1055/s-0033-1357505. Epub 2013 Oct 9.

  PMID: 24108470 BACKGROUND

• Hoirisch-Clapauch S, Mezzasalma MA, Nardi AE. Pivotal role of tissue plasminogen activator in the mechanism of action of electroconvulsive therapy. J Psychopharmacol. 2014 Feb;28(2):99-105. doi: 10.1177/0269881113507639. Epub 2013 Oct 9.

  PMID: 24113086 BACKGROUND

• Hoirisch-Clapauch S, Nardi AE. Markers of low activity of tissue plasminogen activator/plasmin are prevalent in schizophrenia patients. Schizophr Res. 2014 Oct;159(1):118-23. doi: 10.1016/j.schres.2014.08.011. Epub 2014 Sep 7.

  PMID: 25205258 RESULT

MeSH Terms

Conditions

Insulin Resistance; Thrombophilia; Psychotic Disorders

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases; Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Antonio E Nardi, MD, PhD

  Universidade Federal do Rio de Janeiro, Brazil

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Responsible for the HFSE Thrombophilia Clinic

Study Record Dates

• First Submitted: December 5, 2011
• First Posted: December 7, 2011
• Study Start: January 1, 2013
• Primary Completion: May 1, 2013
• Study Completion: May 1, 2013
• Last Updated: December 16, 2014

Record last verified: 2014-12

Locations

BR (1)