Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients

NCT01482988 | Unknown

• 1 other identifier: 11/WA/0340
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The principal aim of this study is to establish if a polymorphism in a gene important for innate immunity to fungi represents a significant risk factor for the development of Candida colonisation and subsequent invasive candidosis in critically ill patients. Incorporation of a screening programme onto a risk-based algorithm for critical care patients would allow more effective targeting of molecular diagnostic tests, anti-fungal prophylaxis and targeted treatment. Sequential critical care patients will be screened for gene polymorphisms and undergo regular screening for Candida colonization.

Conditions

Critically Ill

Keywords

prevalence of the Dectin-1 polymorphism (Tyr238X)

Study Arms (1)

Critical care patients antipated to stay more than 72 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critical care patients predicted to stay more than 72 hours

You may qualify if:

• Patients aged \> 18 years
• Patients with anticipated or actual critical care unit stay \> 72 hours
• Consent or assent (if patient lacks capacity) obtained

You may not qualify if:

• Age \< 18 years
• Length of predicted stay on critical care \< 72 hours consent or assent not obtained

Sponsors & Collaborators

• Cardiff and Vale University Health Board: lead
• Cardiff University: collaborator

Study Sites (1)

Critical Care Unit

University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom

Location

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Rosemary Barnes

  Cardiff University

  PRINCIPAL INVESTIGATOR

• Matt P Wise

  Cardiff and Vale Local Health Board

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Matt P Wise

CONTACT

+44 2920 747747; mattwise@doctors.org.uk

Nicki Haskins

CONTACT

+44 2920 747747; nicki.haskins@wales.nhs.uk

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Critical Care Consultant

Study Record Dates

• First Submitted: November 29, 2011
• First Posted: December 1, 2011
• Study Start: December 1, 2011
• Last Updated: December 1, 2011

Record last verified: 2011-11

Locations

GB (1)