A Study to Assess Pharmacokinetic Interaction of Multiple Dose Ketoconazole on Single Dose YM178 Oral Controlled Absorption System (OCAS) in Healthy Adult Volunteers

NCT01476800 | Completed Phase 1

• 1 other identifier: 178-CL-036
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the pharmacokinetic interaction of multiple-dose ketoconazole on single-dose YM178 OCAS and the safety and tolerability of YM178 OCAS alone and in combination with ketoconazole in healthy adult volunteers.

Conditions

Healthy Subjects; Pharmacokinetics of YM178

Keywords

Drugs, Investigational; pharmacokinetics; Urinary Bladder, Overactive; YM178; Mirabegron

Outcome Measures

Primary Outcomes (2)

• Pharmacokinetic (PK) variable for YM178: Area under the plasma concentration - time curve from time of dosing to infinity (AUCinf)

  Up to Day 7 in Period 1 and up to Day 10 in Perod 2

• PK Variable for YM178: Maximum concentration (Cmax)

  Up to Day 7 in Period 1 and up to Day 10 in Perod 2

Secondary Outcomes (1)

• Safety assessed by recording of adverse events, vital signs, laboratory assessments, electrocardiograms (ECGs) and physical exams

  Up to Day 7 in Period 1 and up to Day 10 in Period 2

Study Arms (3)

YM178 OCAS alone

EXPERIMENTAL

Drug: YM178 OCAS

Ketoconazole alone

ACTIVE COMPARATOR

Drug: Ketoconazole

YM178 OCAS and ketoconazole

EXPERIMENTAL

Drug: YM178 OCAS

Interventions

YM178 OCAS DRUG

oral

Also known as: mirabegron

YM178 OCAS alone; YM178 OCAS and ketoconazole

Ketoconazole DRUG

oral

Also known as: Nizoral

Ketoconazole alone

Eligibility Criteria

• Age: 19 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The subject, if female, must be surgically sterile (must be documented), post-menopausal (defined as at least two years without menses), or must be using double-barrier contraception or a non-hormonal IUD
• The subject, if female, must be non-lactating, and have a negative serum pregnancy test result during the study
• The subject must be in good health
• The subject must weigh at least 45 kg, and have a Body Mass Index (BMI) between 18 and 30 kg/m\^2, inclusive
• The subject must have normal clinical laboratory test results or, if abnormal, are not clinically significant
• The subject must have a normal 12-lead electrocardiogram (ECG) (including normal interval durations). If abnormal, the interval durations must be deemed not clinically significant and must not exceed the following values: PR intervals must not exceed 220 milliseconds and QTc values must not exceed 450 milliseconds in Males or 470 milliseconds in females
• The subject must have negative drug and alcohol toxicology screens during the study. Any subject who tests positive for drugs or alcohol during the study will be terminated

You may not qualify if:

• The subject has a history of clinically significant illness (e.g., cardiovascular, hepatic, renal, or gastrointestinal abnormality within past 3 months that would preclude participation in the study
• The subject is known to have hepatitis or is positive for hepatitis A antibody IgM, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, or has a positive result to tests for HIV-1 and/or HIV-2 antibodies
• The subject is known to have hypersensitivity to YM178, or ketoconazole or other imidazole compounds
• The subject has a resting supine pulse \<50 bpm or \>90 bpm
• The subject has orthostasis (change in pulse rate with orthostatic maneuver of \>20 bpm or to a level ≥ 120 bpm)
• The subject is taking any oral hormonal contraceptive
• The subject is taking a potential inhibitor of CYP3A4 or CYP2D6
• The subject has received or is anticipated to receive a prescription systemic or topical medication within past 14 days or any long-active treatments (e.g., depot formulation) within past 30 days
• The subject has received any other-the-counter medication including herbal medicines within past 14 days (occasional use of acetaminophen of up to 2000 mg/day but not more than 4 days per week is permitted)
• The subject is currently participating in another clinical trial and/or is taking or has been taking an investigational drug in the past 30 days (or 10 half-lives of the drug, whichever is longer)
• The subject anticipates an inability to abstain from alcohol, or caffeine use, or from grapefruit and grapefruit juice from 48 hours prior to the administration of the first dose of YM178 on Day 1 of Period 1 and throughout the duration of the study
• The subject has used tobacco-containing products and nicotine or nicotine-containing products in past six months
• The subject consumes more than 5 units of alcoholic beverages (one unit is 12 ounces of beer, 4 ounces of wine or 1 ounce of spirits) per week or has a history of substance abuse, drug addiction, or alcoholism within past 2 years.
• The subject has had any blood donation or significant loss of blood or has received transfusion of any blood or blood products within 56 days of study initiation or has donated plasma within 7 days of study initiation.
• The subject has a history of psychiatric illness within past 10 years or is incapable of being compliant with the study procedures

Sponsors & Collaborators

• Astellas Pharma Inc: lead

Study Sites (1)

MDS Pharma Services (US) Inc.

Lincoln, Nebraska, 68502, United States

Location

MeSH Terms

Conditions

Urinary Bladder, Overactive

Interventions

mirabegron; Ketoconazole

Condition Hierarchy (Ancestors)

Urinary Bladder Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Piperazines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Officials

• Senior Medical Director

  Astellas Pharma Global Development

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 18, 2011
• First Posted: November 22, 2011
• Study Start: July 1, 2006
• Primary Completion: November 1, 2006
• Study Completion: November 1, 2006
• Last Updated: September 1, 2015

Record last verified: 2015-08

Locations

US (1)