Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

NCT01475812 | Completed

• 1 other identifier: 0353/03
• Study Type: observational
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

Conditions

Dynamic Lung Hyperinflation; COPD Patients; Activities of Daily Livin.

Keywords

COPD; activities of daily living; pulmonary hyperinflation; exercise

Outcome Measures

Primary Outcomes (1)

• Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.

  3 months

Study Arms (1)

COPD hyperinflation

Other: Hyperinflation and ADL

Interventions

Hyperinflation and ADL OTHER

Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

COPD hyperinflation

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.

You may qualify if:

• COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
• clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

You may not qualify if:

• Inability to perform the slow vital capacity maneuver
• excessive perceived dyspnea during the test
• arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation

Sponsors & Collaborators

• Federal University of São Paulo: lead

Study Sites (1)

Federal University of São Paulo

São Paulo, São Paulo/SP, 05414000, Brazil

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity

Interventions

Activities of Daily Living

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: November 17, 2011
• First Posted: November 21, 2011
• Study Start: March 1, 2007
• Last Updated: November 21, 2011

Record last verified: 2011-11

Locations

BR (1)