The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase

NCT01467674 | Completed

• 1 other identifier: 1721-D-08
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the impact of glycemic control on clinical periodontal status, levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and paraoxonase (PON) activity in gingival crevicular fluid (GCF) and blood samples of type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP).

Conditions

Type 2 Diabetes Mellitus; Chronic Periodontitis

Keywords

Diabetes mellitus; Chronic periodontitis; Malondialdehyde; Glutathione peroxidase; Paraoxonase

Outcome Measures

Primary Outcomes (1)

• HbA1c

  Level of Metabolic Control

  One Year

Secondary Outcomes (1)

• Clinical Periodontal Status

  One Year

Study Arms (4)

Healthy

Chronic Periodontitis

Better Controlled T2DM

Poor Controlled T2DM

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with T2DM were recruited among those attending Suleyman Demirel University (SDU) Faculty of Medicine, Department of Endocrinology and non-diabetic individuals were recruited among those attending SDU Faculty of Dentistry, Department of Periodontology.

You may qualify if:

• to present T2DM diagnosis by an endocrinologist for at least the past 5 years
• diagnosis of CP was based on the clinical and radiographic criteria proposed by the 1999 World Workshop for Classification of Periodontal Diseases and Conditions

You may not qualify if:

• pregnancy
• lactation
• current smoking or smoking within the past 2 years, periodontal therapy in the previous 6 months
• antibiotic and/or antimicrobial therapies in the previous 3 months
• existence of serious diabetic complications or any pathology such as haemoglobinopathy which would affect haemoglobin profile
• diagnosis of another major medical pathology, middle or upper-level obesity according to WHO classification
• current anti-hyperlipidemic therapy
• non-T2DM patients with abnormal values of glucose and lipid metabolism parameters, major medical pathology and family history of DM

Sponsors & Collaborators

• Suleyman Demirel University: lead

Study Sites (1)

Suleyman Demirel University

Isparta, 32260, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Chronic Periodontitis; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• F. Yeşim Kırzıoğlu, 1

  Professor, Periodontology Dept

  STUDY DIRECTOR

• Mustafa Nazıroğlu, 1

  Professor, Biophysics Dept

  STUDY DIRECTOR

• M. Numan Tamer, 1

  Professor, Internal Diseases Dept.

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 1, 2011
• First Posted: November 9, 2011
• Study Start: January 1, 2008
• Primary Completion: May 1, 2009
• Study Completion: May 1, 2009
• Last Updated: November 9, 2011

Record last verified: 2011-11

Locations

TU (1)