NCT01467024

Brief Summary

The purpose of this study is:

  1. 1.To assess the validity and reproducibility of the MP Diagnostics HTLV Blot 2.4.
  2. 2.To conduct a sensitivity analysis of the HTLV Blot 2.4 using a known positive population.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
600

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2011

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 31, 2011

Completed
1 day until next milestone

Study Start

First participant enrolled

November 1, 2011

Completed
7 days until next milestone

First Posted

Study publicly available on registry

November 8, 2011

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2012

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2012

Completed
Last Updated

November 8, 2011

Status Verified

November 1, 2011

Enrollment Period

2 months

First QC Date

October 31, 2011

Last Update Submit

November 7, 2011

Conditions

Keywords

HTLVConfirmatorySupplementalBlotHTLV-IHTLV-II

Study Arms (3)

EIA Negative

Blood donor specimens that tested non-reactive by previously licensed HTLV screening assay.

Other: CDPHL Algorithm

EIA Repeat Reactive

Blood donor specimens that tested repeat reactive by previously licensed HTLV screening assay, but are unconfirmed.

Other: CDPHL Algorithm

Known Positive

Blood donor specimens that tested repeat reactive with a licensed HTLV screening assay and have been confirmed through additional, unlicensed supplemental testing.

Other: CDPHL Algorithm

Interventions

Supplemental testing algorithm performed by the CDPHL.

EIA NegativeEIA Repeat ReactiveKnown Positive

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All populations are from whole blood donors.

You may qualify if:

  • EIA Negative Population
  • Male or female
  • Completion of a health history evaluation for routine donor screening
  • Willing and able to provide informed consent
  • Negative screening assay results for all ARC screening assays
  • EIA Repeat Reactive Population
  • Male or female
  • Completion of a health history evaluation for routine donor screening
  • Willing and able to provide informed consent
  • Previous RR result by bioMerieux ELISA, Abbott EIA, and / or Abbott ChLIA PRISM
  • Known Positive Population
  • Male or female
  • Willing and able to provide informed consent
  • Previous reactive screening test using either the bioMerieux ELISA, the Abbott EIA or the Abbott ChLIA PRISM, followed by supplemental testing

You may not qualify if:

  • EIA Negative Population
  • Inadequate sample volume for testing
  • Unable to provide samples that meet the sample suitability requirements for testing
  • Positive screening result for any infectious disease tested by ARC
  • EIA Repeat Reactive Population
  • Inadequate sample volume for testing
  • Unable to provide samples that meet the sample suitability requirements for testing
  • Positive result for HIV, HBV, HCV, or any other infectious disease
  • Known Positive Population
  • Unwilling or unable to provide informed consent
  • Unable to provide adequate sample volume for testing
  • Unable to provide samples that meet the sample suitability requirements for testing
  • Positive result for HIV

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

California Department of Public Health

Richmond, California, 94804, United States

Location

LABS, Inc

St Louis, Missouri, 38611, United States

Location

MeSH Terms

Conditions

HTLV-I InfectionsHTLV-II InfectionsLeukemia-Lymphoma, Adult T-CellParaparesis, Tropical Spastic

Condition Hierarchy (Ancestors)

Deltaretrovirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesInfectionsImmunologic Deficiency SyndromesImmune System DiseasesLeukemia, T-CellLeukemia, LymphoidLeukemiaNeoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLymphoproliferative DisordersLymphatic DiseasesImmunoproliferative DisordersMyelitisCentral Nervous System InfectionsCentral Nervous System DiseasesNervous System DiseasesSpinal Cord DiseasesNeuroinflammatory Diseases

Study Officials

  • Susan Stramer, Ph.D

    American National Red Cross

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 31, 2011

First Posted

November 8, 2011

Study Start

November 1, 2011

Primary Completion

January 1, 2012

Study Completion

June 1, 2012

Last Updated

November 8, 2011

Record last verified: 2011-11

Locations