NCT01462734

Brief Summary

MicroRNAs are important regulators of many cellular functions but their expression profile in human vitreous is still unclear. Aim of this study is to investigate microRNA expression profile by PCR in human vitreous of macula hole patients which is suggested to be similar to that of healthy patients.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8

participants targeted

Target at below P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2011

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

October 26, 2011

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 31, 2011

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2014

Completed
Last Updated

April 1, 2015

Status Verified

March 1, 2015

Enrollment Period

3.2 years

First QC Date

October 26, 2011

Last Update Submit

March 31, 2015

Conditions

MicroRNA Expression Profile in Human Vitreous

Outcome Measures

Primary Outcomes (1)

  • MicroRNA expression profile in human vitreous investigated by PCR

    1month

Study Arms (1)

human vitreous, human blood serum, PCR

Vitreous and bloodserum samples from macula hole patients without previous ocular or systemic disease

Procedure: human vitreous and blood serum sampling, PCR

Interventions

human vitreous and blood serum sampling, PCRPROCEDURE

1ml of human vitreous and 3ml of human blood serum

human vitreous, human blood serum, PCR

Eligibility Criteria

Sexfemale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Female pateints undergoing vitrectomy for macula hole without previous ocular or systemic disease

You may qualify if:

  • Female macula hole patients without previous ocular or systemic disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kyorin University School Of Medicine

Tokyo, Mitakasi Sinkawa6-20-2, 181-8611, Japan

Location

Biospecimen

Retention: SAMPLES WITH DNA

3ml of blood serum and 1ml of vitreous

MeSH Terms

Interventions

Polymerase Chain Reaction

Intervention Hierarchy (Ancestors)

Nucleic Acid Amplification TechniquesGenetic TechniquesInvestigative Techniques

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

October 26, 2011

First Posted

October 31, 2011

Study Start

October 1, 2011

Primary Completion

December 1, 2014

Last Updated

April 1, 2015

Record last verified: 2015-03

Locations

JP(1)