Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery
RECR-CABG
Comparison of Different Types of Postoperative Pulmonary Recruitment and Predicting Its Efficacy Following Off-pump Coronary Artery Bypass Grafting
1 other identifier
interventional
76
1 country
1
Brief Summary
The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism. The investigators compare three different types of alveolar recruitment in patient after cardiac surgery, to reveal which one is better.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2010
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 20, 2011
CompletedFirst Posted
Study publicly available on registry
October 24, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedJune 25, 2013
June 1, 2013
1.8 years
October 20, 2011
June 24, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Respiratory support
The duration of the postoperative respiratory support
24 hrs
Secondary Outcomes (4)
The incidence of postoperative atelectasis
24 hrs
Incidence of reintubation
24 Hrs
Oxygenation
12 hrs after extubation
Length of ICU and hospital stay
28 Days
Study Arms (4)
Recruitment 40x40
ACTIVE COMPARATORThe group where recruitment is performed by increase in airway pressure up to 40 cm H2O for 40 seconds
Recruitment PEAK40
ACTIVE COMPARATORIncrease in peak airway pressure up to 40 cm H2O during tidal ventilation
Recruitment 15x300
ACTIVE COMPARATORRecruitment by increase in airway PEEP up to 15 cm H2O for 300 sec
No recruitment
ACTIVE COMPARATORNo recruitment is performed: standard respiratory support.
Interventions
Four approaches: 1. CPAP 40 cm H2O 2. Peak pressure 40 cm H2O 3. PEEP 15 cm H2O for 300 sec 4. no intervention (controls)
Eligibility Criteria
You may qualify if:
- Age between 18 and 75
- Off-pump coronary artery bypass grafting
- Possibility to discontinue respiratory support in the first day after intervention
You may not qualify if:
- Signs of ARDS
- COPD in decompensation phase
- Requirement for inotropic support(epinephrine \>0,1 mcg/kg/hr)
- Bronchiectases
- Pregnancy
- Morbid obesity
- Aortic aneurism
- AMI in previous month
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
City hospital # 1
Arkhangelsk, Arkhangelskaya oblast, 163000, Russia
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Mikhail Y. Kirov, MD, PhD
Northern State Medical University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor, MD, PhD
Study Record Dates
First Submitted
October 20, 2011
First Posted
October 24, 2011
Study Start
March 1, 2010
Primary Completion
December 1, 2011
Study Completion
January 1, 2012
Last Updated
June 25, 2013
Record last verified: 2013-06