The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient

NCT01457534 | Completed

• 1 other identifier: 4-2010-0671
• Study Type: observational
• Target: 148
• Locations: 1 country
• Sites: 1

Brief Summary

Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival. However, there are few reports to assess the predictors for postoperative CRRT in liver transplant patients. The investigators undertook this study to identify perioperative factors that would predict patients at risk of CRRT. Patients and Methods. The investigators retrospectively reviewed the data of 148 liver transplant patients from January 2007 to November 2010 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104. Univariate and stepwise logistic multivariate analyses were performed.

Conditions

Liver Transplantation

Outcome Measures

Primary Outcomes (11)

• status before operation

  laboratory data(ex : total bilirubin, albumin, coagulation factors, blood gas analysis(arterial CO2 pressure. Blood urea nitrate/Creatinine, Hemoglobin/Hematocrit.)

  1 day before operation

• the amount of ascites

  intraoperative

• the duration of anesthesia and operation

  intraoperative

• intraoperative hemodynamic instability

  intraoperative

• intraoperative bleeding

  intraoperative

• Intraoperative urine output

  intraoperative

• the types of donation(living or deceased donor)

  intraoperative

• survival rate

  on the postoperative 28th days, 365 days

• postoperative bleeding amount

  on the postoperative 28th days, 365 days.

• postoperative CRRT(continuous renal replacement therapy),

  on the postoperative 28th days, 365days

• mortality

  on the postoperative 28th days, 365 days.

Study Arms (1)

liver transplantation

Eligibility Criteria

• Age: 19 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

the data of 148 liver transplant patients from January 2008 to December 2011 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104.

You may qualify if:

• Age 19-65 year
• Liver transplant patients from January 2008 to December 2011

You may not qualify if:

• Patients treated with CRRT before transplantation

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Severance Hospital

Seoul, Seoul, 120-752, South Korea

Location

Related Publications (5)

• Wong LP, Blackley MP, Andreoni KA, Chin H, Falk RJ, Klemmer PJ. Survival of liver transplant candidates with acute renal failure receiving renal replacement therapy. Kidney Int. 2005 Jul;68(1):362-70. doi: 10.1111/j.1523-1755.2005.00408.x.

  PMID: 15954928 BACKGROUND

• Wu CC, Yeung LK, Tsai WS, Tseng CF, Chu P, Huang TY, Lin YF, Lu KC. Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis. Clin Nephrol. 2006 Jan;65(1):28-33. doi: 10.5414/cnp65028.

  PMID: 16429839 BACKGROUND

• Gonwa TA, Mai ML, Melton LB, Hays SR, Goldstein RM, Levy MF, Klintmalm GB. Renal replacement therapy and orthotopic liver transplantation: the role of continuous veno-venous hemodialysis. Transplantation. 2001 May 27;71(10):1424-8. doi: 10.1097/00007890-200105270-00012.

  PMID: 11391230 BACKGROUND

• Holt AW, Bierer P, Bersten AD, Bury LK, Vedig AE. Continuous renal replacement therapy in critically ill patients: monitoring circuit function. Anaesth Intensive Care. 1996 Aug;24(4):423-9. doi: 10.1177/0310057X9602400402.

  PMID: 8862637 BACKGROUND

• Matsubara S, Okabe K, Ouchi K, Miyazaki Y, Yajima Y, Suzuki H, Otsuki M, Matsuno S. Continuous removal of middle molecules by hemofiltration in patients with acute liver failure. Crit Care Med. 1990 Dec;18(12):1331-8. doi: 10.1097/00003246-199012000-00005.

  PMID: 2245605 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 4, 2011
• First Posted: October 24, 2011
• Study Start: January 1, 2011
• Primary Completion: February 1, 2011
• Study Completion: February 1, 2011
• Last Updated: February 27, 2013

Record last verified: 2013-02

Locations

KR (1)