NCT01456806

Brief Summary

Objective: To evaluate the effect of system interventions (data recording procedures and complete coverage of medications and supplies) with or without physician and/or patient education, upon the psychological, clinical, metabolic and therapeutic indicators and the costs of care of people with type 2 diabetes. Design: Randomized 2x2 design; sample size was determined considering the change in haemoglobin A1c (primary outcome variable) using a two-sided test at the 5% level of significance, and 80% power using a paired t-test. Sample size was increased by 25% to account for non-independence and patient drop-out. Setting: Primary care level in the city of Corrientes, Argentina with involvement of all three Argentinean health subsectors (public health, social security and the private, prepaid system). Participants: 36 general practitioners and 468 adults (62-71% women, mean age 62 years) with type 2 diabetes. Patients of the participating physicians (nine in each group), were randomly selected and assigned to one of four groups (117 patients each): control, provider education, patient education, and provider/patient education. Intervention: Structured group education programmes were delivered to provider and/or people with type 2 diabetes by trained professionals; identical system interventions were applied to all four groups. Main outcome measures: Body mass index, blood pressure, fasting glucose, haemoglobin A1c levels, lipid profile, drug consumption, resource use, and patient well being (WHO-5 questionnaire and Lowe score), at baseline and up to 42 months at every 6 months intervals.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
468

participants targeted

Target at P75+ for not_applicable type-2-diabetes

Timeline
Completed

Started Dec 2006

Longer than P75 for not_applicable type-2-diabetes

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2006

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2007

Completed
3.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2010

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

October 19, 2011

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 21, 2011

Completed
Last Updated

October 21, 2011

Status Verified

October 1, 2011

Enrollment Period

3 months

First QC Date

October 19, 2011

Last Update Submit

October 20, 2011

Conditions

Keywords

T2DMCardiovascular risk factorsMetabolic controlWell-beingCostCost-consequence

Outcome Measures

Primary Outcomes (1)

  • HbA1c

    42 months

Secondary Outcomes (1)

  • Quality of Care Indicators

    42 months

Study Arms (4)

Patients and provider non educated

NO INTERVENTION

In this arm neither the patients nor the providers have attended the groupal education courses

Other: Education

Provider educated

ACTIVE COMPARATOR

Provider attend the interactive group education, while patients do not.

Other: Education

Patients Educated

ACTIVE COMPARATOR

Patients attend the interactive group education, while providers do not.

Other: Education

Providers/Patients Educated

ACTIVE COMPARATOR

Provider and Patients both attend the interactive group education.

Other: Education

Interventions

Structured group education programmes were delivered to provider and/or people with type 2 diabetes by trained professionals; identical system interventions were applied to all four groups.

Also known as: Diabetes Education
Patients EducatedPatients and provider non educatedProvider educatedProviders/Patients Educated

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults Patients with type 2 diabetes
  • Being regularly attended at the doctors office during at least one year

You may not qualify if:

  • Newly diagnosed type 2 diabetes
  • Advanced stage of chronics complications (End-stage-kidney disease)
  • Heart Failure.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CENEXA (UNLP-CONICET La PLata)

La Plata, Buenos Aires, 1900, Argentina

Location

Related Publications (2)

  • Gagliardino JJ, Lapertosa S, Villagra M, Caporale JE, Oliver P, Gonzalez C, Siri F, Clark Ch Jr; PRODIACOR. PRODIACOR: a patient-centered treatment program for type 2 diabetes and associated cardiovascular risk factors in the city of Corrientes, Argentina: study design and baseline data. Contemp Clin Trials. 2007 Jul;28(4):548-56. doi: 10.1016/j.cct.2007.01.004. Epub 2007 Jan 12.

    PMID: 17331807BACKGROUND
  • Gagliardino JJ, Lapertosa S, Pfirter G, Villagra M, Caporale JE, Gonzalez CD, Elgart J, Gonzalez L, Cernadas C, Rucci E, Clark C Jr; PRODIACOR. Clinical, metabolic and psychological outcomes and treatment costs of a prospective randomized trial based on different educational strategies to improve diabetes care (PRODIACOR). Diabet Med. 2013 Sep;30(9):1102-11. doi: 10.1111/dme.12230. Epub 2013 Jun 7.

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Educational Status

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

Socioeconomic FactorsPopulation Characteristics

Study Officials

  • Juan J Gagliardino, MD

    CENEXA (UNLP-CONICET La Plata)

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 19, 2011

First Posted

October 21, 2011

Study Start

December 1, 2006

Primary Completion

March 1, 2007

Study Completion

July 1, 2010

Last Updated

October 21, 2011

Record last verified: 2011-10

Locations