Influence of Anesthesia Drugs on Impedance Aggregometry
The Influence of Drugs Routinely Used in Cardiac Anesthesia on Impedance Aggregometry.
1 other identifier
observational
20
1 country
1
Brief Summary
Impedance aggregometry (IA) (Multiplate®)is a new whole blood platelet function test with potential use in anesthesia and intensive care. Most anesthetic drugs have been shown to have in vitro antiplatelet activity. The goal of this in vitro study is to evaluate the effect of several drugs, frequently used in cardiac anesthesia and intensive care, on platelet function as measured by IA
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2010
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2011
CompletedFirst Submitted
Initial submission to the registry
October 18, 2011
CompletedFirst Posted
Study publicly available on registry
October 19, 2011
CompletedOctober 19, 2011
October 1, 2011
7 months
October 18, 2011
October 18, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
Drug induced platelet dysfunction as measured by impedance aggregometry.
Study Arms (1)
healthy volunteers
Eligibility Criteria
Healthy volunteers
You may qualify if:
- Age 18 to 65 years old
You may not qualify if:
- Use of non-steroidal anti-inflammatory drugs for 2 weeks prior to donation.
- Known coagulation disorders.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Lausanne Hospitals
Lausanne, Canton of Vaud, 1011, Switzerland
Related Publications (1)
Morisoli AP, Gronchi F, Ferrari E, Blanc C, Frascarolo P, Angelillo-Scherrer A, Marcucci C. The influence of drugs used in cardiac anaesthesia and critical care on multiple electrode aggregometry: an in-vitro volunteer study. Eur J Anaesthesiol. 2014 Sep;31(9):499-504. doi: 10.1097/EJA.0000000000000113.
PMID: 25010745DERIVED
Biospecimen
Whole blood
Study Officials
- PRINCIPAL INVESTIGATOR
Carlo E Marcucci, MD
University of Lausanne Hospitals
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 18, 2011
First Posted
October 19, 2011
Study Start
October 1, 2010
Primary Completion
May 1, 2011
Study Completion
May 1, 2011
Last Updated
October 19, 2011
Record last verified: 2011-10