Tick-borne Illness and Clothing Study

NCT01454414 | Completed Results

• 1 other identifier: 10-1027
• Study Type: interventional
• Target: 159
• Locations: 1 country
• Sites: 1

Brief Summary

The high risk of acquiring tick-borne diseases by outdoor workers is well documented. Workers most at risk include, foresters, park rangers, land surveyors and other outdoor workers have frequent exposure to tick-infested habitats. Many North Carolina state employees with outdoor occupations report multiple tick bites each year, which indicates that existing tick preventive strategies may be ineffective. The principal goal of this study is to assess whether the use of long-lasting permethrin impregnated uniforms can reduce the number of tick bites sustained by North Carolina outdoor workers.

Conditions

Tick Bites; Tick-borne Illness

Outcome Measures

Primary Outcomes (1)

• Work Related Tick Bites

  Tick bites are defined as ticks attached to or embedded in the skin

  Weekly for two years

Secondary Outcomes (1)

• Seroconversion Against a Tick-borne Illness

  Upon enrollment, after the first year, and after the second year

Study Arms (2)

Permethrin Impregnated Uniforms

EXPERIMENTAL

Uniforms (including pants, shorts, shirts, socks, and hats) treated with long-lasting permethrin.

Other: Permethrin Impregnated Uniforms

Placebo

NO INTERVENTION

Uniforms sent to Insect Shield, washed and refolded (no permethrin applied).

Interventions

Permethrin Impregnated Uniforms OTHER

Uniforms treated with permethrin according to proprietary process used by Insect Shield, Inc.

Also known as: Insect Shield

Permethrin Impregnated Uniforms

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being over 18 years of age
• Employee of NC Division of Forest Resources, the NC Division of Parks and Recreation, NC Wildlife Resources Commission, or NC County and Local Parks and Recreation who work in Central and Eastern North Carolina
• An average of 10 or more hours of outdoor work per week during tick season
• Self-reported prior work-related tick bites

You may not qualify if:

• Pregnancy
• Non-English speaking
• Known allergy to insecticides

Sponsors & Collaborators

• University of North Carolina, Chapel Hill: lead
• North Carolina State University: collaborator

Study Sites (1)

Gillings School of Global Public Health

Chapel Hill, North Carolina, 27599, United States

Location

Related Publications (1)

• Vaughn MF, Funkhouser SW, Lin FC, Fine J, Juliano JJ, Apperson CS, Meshnick SR. Long-lasting permethrin impregnated uniforms: A randomized-controlled trial for tick bite prevention. Am J Prev Med. 2014 May;46(5):473-80. doi: 10.1016/j.amepre.2014.01.008.

  PMID: 24745637 RESULT

MeSH Terms

Conditions

Tick Bites

Condition Hierarchy (Ancestors)

Bites and Stings; Poisoning; Chemically-Induced Disorders; Wounds and Injuries

Results Point of Contact

• Title: Dr. Meagan Vaughn
• Organization: University of North Carolina at Chapel Hill

meagan.vaughn@unc.edu

9196986208

Study Officials

• Steven R Meshnick, MD, PhD

  University of North Carolina, Chapel Hill

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 10, 2011
• First Posted: October 19, 2011
• Study Start: October 1, 2010
• Primary Completion: October 1, 2012
• Study Completion: April 1, 2013
• Last Updated: March 30, 2021
• Results First Posted: June 30, 2014

Record last verified: 2014-05

Locations

US (1)