A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer

NCT01452971 | Unknown DMC

• 1 other identifier: DMR99-IRB-196
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

Environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs) were reviewed as the major risk factors for lung cancer development. In this proposal, the investigators collected fifteen kinds of major PAHs and the investigators would like to perform the following studies:

1. 1.Study the gene expression and subcellular localization of GNMT in the normal-tumor tissue pairs of lung cancer patients.
2. 2.Study the associations of the polymorphisms of GNMT in lung cancer patients and the susceptibility to lung cancer;
3. 3.To assess the allelic loss at GNMT and determined the LOH rate of GNMT in the normal-tumor tissue pairs of lung cancer patients.
4. 4.Study the associations of the copy number variation (CNV) of GNMT and the susceptibility to lung cancer;
5. 5.Study the interaction between GNMT and polycyclic aromatic hydrocarbons (PAHs) in lung cancer cell lines.

Conditions

Lung Cancer

Keywords

tumor susceptibility gene; glycine N-methyltransferase (GNMT); polycyclic aromatic hydrocarbons (PAHs); lung cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

primary care clinic

You may qualify if:

• Participant is a lung cancer patient.

You may not qualify if:

• Participant is under 18 years old.
• Participant is not a lung cancer patient.

Sponsors & Collaborators

• China Medical University Hospital: lead

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 13, 2011
• First Posted: October 17, 2011
• Study Start: October 1, 2011
• Last Updated: October 17, 2011

Record last verified: 2011-10