Breath Test for Chemicals (Volatile Organic Compounds)

NCT01437033 | Completed

• 2 other identifiers: 99991124311-C-N243
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- Some types of cancer, like cancer of the esophagus, are difficult to detect at an early stage. A possible detection method involves collecting breath samples to look for chemicals that may be signs of cancer. However, more research is needed to determine how different chemicals appear in different breath samples. This study will involve healthy volunteers. Objectives: \- To study chemicals appearing in breath samples of healthy volunteers. Eligibility: \- Healthy volunteers between 30 and 60 years of age. Design:

• Participants will fast overnight (midnight to morning) and then provide two breath samples taken 5 minutes apart.
• Breath samples will be collected on days 1, 49, and 98 of the study

Conditions

Breath Tests; Human Volunteers; Pilot Study

Keywords

Breath Tests; Human Volunteers; Pilot Study; Breath Test

Outcome Measures

Primary Outcomes (1)

• Statistics of robustness (CV, ICCs)

  98 days

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• DCEG volunteers aged 30-60 years, inclusive.

You may not qualify if:

• Aged less than 30 years. Aged 61 years or older. Individuals who identify themselves to be in any one of the following categories over the next 4 month period:
• Plan to initial a large change in their daily amount of physical activity
• Plan to make large changes to their diet (reduce caloric intake, become a vegetarian etc)
• May possibly move away from the area for a new job, sabbatical, retirement etc
• Plan to attempt to become pregnant
• Have limited availability for any reason including prolonged vacation or business travel

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

National Cancer Institute (NCI), 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Cook MB, Dawsey SM, Diaw L, Blaser MJ, Perez-Perez GI, Abnet CC, Taylor PR, Albanes D, Virtamo J, Kamangar F. Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1966-75. doi: 10.1158/1055-9965.EPI-10-0270. Epub 2010 Jul 20.

  PMID: 20647397 BACKGROUND

• Vizcaino AP, Moreno V, Lambert R, Parkin DM. Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973-1995. Int J Cancer. 2002 Jun 20;99(6):860-8. doi: 10.1002/ijc.10427.

  PMID: 12115489 BACKGROUND

• Perera FP. Cancer: the big questions to address in coming years. Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):571-3. doi: 10.1158/1055-9965.EPI-11-0184. No abstract available.

  PMID: 21454418 BACKGROUND

Study Officials

• Michael B Cook, M.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 16, 2011
• First Posted: September 20, 2011
• Study Start: August 29, 2011
• Study Completion: September 23, 2016
• Last Updated: April 5, 2018

Record last verified: 2016-09-23

Locations

US (1)