NCT01432899|Completed
Studying Childhood-Onset Hemidystonia
Characteristics and Mechanism of Childhood-Onset Hemidystonia
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Characteristics and Mechanism of Childhood-Onset Hemidystonia
Sponsor study identifier
Secondary identifiers
observational
21
1 country
1
Study Start
September 10, 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
December 20, 2018
Date type not reportedThis date has not been verified as actual or estimated.
Background: \- Childhood-onset dystonia is caused by a brain injury. It causes muscle contractions and twisting movements that the person with dystonia cannot control. The term hemidystonia is used when only one side of the body is affected. When dystonia starts during childhood, the brain and nerves may not develop normally. People with hemidystonia can become disabled because of the unwanted postures and twisting that dystonia causes. More research is needed to determine how dystonia affects brain development. Objectives: \- To study brain function in people with hemidystonia. Eligibility:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 20, 2018
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 10, 2011
Actual (reported)September 10, 2011
Date type not reportedThis date has not been verified as actual or estimated.
September 13, 2011
Actual (reported)December 20, 2018
Date type not reportedThis date has not been verified as actual or estimated.
Sum of wrist, elbow, and shoulder excursion
Difference between the peak-to-peak amplitude of MEP due to the TS and the CS for SICI.
Performance accuracy on sterognosis.
Maximum excursion and Time to largest hand aperture
This protocol has 5 Objectives, each with its own primary and secondary objectives. They are too numerous to list.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Abbruzzese G, Berardelli A. Sensorimotor integration in movement disorders. Mov Disord. 2003 Mar;18(3):231-240. doi: 10.1002/mds.10327.
Aertsen AM, Gerstein GL, Habib MK, Palm G. Dynamics of neuronal firing correlation: modulation of "effective connectivity". J Neurophysiol. 1989 May;61(5):900-17. doi: 10.1152/jn.1989.61.5.900.
Albanese A, Barnes MP, Bhatia KP, Fernandez-Alvarez E, Filippini G, Gasser T, Krauss JK, Newton A, Rektor I, Savoiardo M, Valls-Sole J. A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. Eur J Neurol. 2006 May;13(5):433-44. doi: 10.1111/j.1468-1331.2006.01537.x.
Diane L Damiano, Ph.D.
National Institutes of Health Clinical Center (CC)
21 participants (actual enrollment reported by the registry).
First Submitted
September 10, 2011
First Posted
September 13, 2011
Study Start
September 10, 2011
Date type not reportedThis date has not been verified as actual or estimated.
Fatigue in Dystonia (a Single Session, Questionnaire-based Study of Fatigue in Dystonia)
Contact the study team to confirm eligibility.
de Campos AC, Kukke SN, Hallett M, Alter KE, Damiano DL. Characteristics of bilateral hand function in individuals with unilateral dystonia due to perinatal stroke: sensory and motor aspects. J Child Neurol. 2014 May;29(5):623-32. doi: 10.1177/0883073813512523. Epub 2014 Jan 5.
Study Completion
December 20, 2018
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
December 24, 2018
Record last verified: 2018-12-20
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