Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

NCT01427231 | Completed

• 1 other identifier: NL36813.081.11
• Study Type: interventional
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

Conditions

Mental Health; Cognition; Memory; Attention

Keywords

Cognitive performance; Attention; Memory; Glucose; Sacharose; Elderly; Memory complaints

Outcome Measures

Primary Outcomes (1)

• Performance on the paired associate recall test

  Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed

  cognitive tests will start 15 minutes after ingestion of the intervention product

Secondary Outcomes (3)

• Mood

  within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink)

• Blood glucose response

  from baseline till 90 minutes after consuming the drink

• Plasma insulin levels

  At t= -15 minutes, before consuming the test drink

Study Arms (3)

Drink with 50 g glucose

ACTIVE COMPARATOR

The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice.

Dietary Supplement: glucose

Drink with 100 gram of sacharose

ACTIVE COMPARATOR

The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice.

Dietary Supplement: sacharose

Placebo with sweeteners

PLACEBO COMPARATOR

The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink).

Dietary Supplement: Placebo

Interventions

glucose DIETARY_SUPPLEMENT

The effect of a glucose solution on cognitive performance will be measured.

Also known as: Sucrose, sugar.

Drink with 50 g glucose

sacharose DIETARY_SUPPLEMENT

The effect of a sacharose solution on cognitive performance will be measured.

Drink with 100 gram of sacharose

Placebo DIETARY_SUPPLEMENT

The effect of a placebo drink with sweeteners on cognitive performance will be measured.

Placebo with sweeteners

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Men and women
• years and older
• Memory complaints

You may not qualify if:

• Type I or II diabetes
• Parkinson disease
• MMSE \< 25 (to exclude cognitively impaired subjects
• CES-D \> 16 (to exclude depressive subjects)
• Pharmacological antidepressives or medication for dementia
• Liver disease

Sponsors & Collaborators

• Wageningen University: lead
• Suikerstichting Nederland (Baarn): collaborator

Study Sites (1)

Wageningen University

Wageningen, Gelderland, 6703 HD, Netherlands

Location

MeSH Terms

Conditions

Psychological Well-Being

Interventions

Glucose; Sucrose; Sugars

Condition Hierarchy (Ancestors)

Personal Satisfaction; Behavior

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Carbohydrates; Disaccharides; Oligosaccharides; Polysaccharides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: August 26, 2011
• First Posted: September 1, 2011
• Study Start: August 1, 2011
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: March 21, 2012

Record last verified: 2012-03

Locations

NL (1)