Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome
ProgBBN
Association Between Progesterone Levels on the Day of Ovulation Induction and IVF Outcome: Retrospective Study With 2500 Controlled Ovarian Stimulations Cycles
2 other identifiers
observational
2,555
1 country
1
Brief Summary
Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome. The hypothesis is that higher progesterone levels are associated with lower implantation rates due to changes in the endometrial receptivity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 28, 2011
CompletedFirst Posted
Study publicly available on registry
August 31, 2011
CompletedAugust 31, 2011
August 1, 2011
5.2 years
August 28, 2011
August 29, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ongoing pregnancy rate
Patients will be followed up from embryotransfer until second trimester of pregnancy
13 weeks
Secondary Outcomes (1)
Delivery after 23.gestational weeks
9 months
Study Arms (3)
Low level progesterone group (1)
Progesterone \< 1.50 ng/mL on day of ovulation induction
Medium level progesterone group (2)
Progesterone 1.51-1.99 ng/mL on the day of ovulation induction
High level progesterone group (3)
Progesterone \> 1.99 ng/mL on the day of ovulation induction
Eligibility Criteria
Female patients with infertility undergoing assisted reproduction techniques, i.e. in vitro fertilization.
You may qualify if:
- IVF/ICSI following controlled ovarian stimulation
- progesterone measured on the day of ovulation induction
- informed consent
You may not qualify if:
- missing consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Praxis Bollmann-Brückner-Noss
Munich, Bavaria, 80331, Germany
Related Publications (1)
Ochsenkuhn R, Arzberger A, von Schonfeldt V, Gallwas J, Rogenhofer N, Crispin A, Thaler CJ, Noss U. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers. Fertil Steril. 2012 Aug;98(2):347-54. doi: 10.1016/j.fertnstert.2012.04.041. Epub 2012 May 24.
PMID: 22633265DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert Ochsenkuehn, MD
Center for Reproductive Medicine
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 28, 2011
First Posted
August 31, 2011
Study Start
January 1, 2006
Primary Completion
April 1, 2011
Study Completion
April 1, 2011
Last Updated
August 31, 2011
Record last verified: 2011-08