Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

NCT01421784 | Terminated DMC

• 1 other identifier: STU 042011-034
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.

Conditions

Lung Cancer

Outcome Measures

Primary Outcomes (1)

• To measure time series of MRI imaging by the b-SSFP sequence.

  To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.

  6 weeks

Study Arms (1)

Cine-MRI

OTHER

Rapid Cine-MRI

Other: cine MRI

Interventions

cine MRI OTHER

Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Cine-MRI

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.
• Any types and amounts of prior therapy will be allowed for this study.
• Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
• Ability to understand and the willingness to sign a written informed consent document.
• Able to tolerate supine position
• ECOG performance status of 3 or less

You may not qualify if:

• MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
• Women who are pregnant or trying to get pregnant
• Pain in supine position

Sponsors & Collaborators

• University of Texas Southwestern Medical Center: lead

Study Sites (1)

UT Southwestern Medical Center

Dallas, Texas, 75390, United States

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Amit Sawant, Ph.D.

  University of Texas Southwestern Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 10, 2011
• First Posted: August 23, 2011
• Study Start: September 1, 2011
• Primary Completion: November 25, 2015
• Study Completion: November 25, 2015
• Last Updated: August 20, 2020

Record last verified: 2018-06

Locations

US (1)