NCT01420120

Brief Summary

This is a prospective multicenter registry to evaluate safety and performance of the REMEDY, biodegradable peripheral stent for the treatment of occluded or stenotic superficial femoral arteries. Patients will be followed for a period of 1 year.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2011

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2011

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

August 16, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

August 19, 2011

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2014

Completed
Last Updated

July 16, 2015

Status Verified

July 1, 2015

Enrollment Period

3.7 years

First QC Date

August 16, 2011

Last Update Submit

July 15, 2015

Conditions

Keywords

Biodegradable stent, PAD

Outcome Measures

Primary Outcomes (1)

  • Absence of clinically driven target lesion revascularization at 12 months.

    12 months

Secondary Outcomes (7)

  • Technical success

    During procedure

  • Clinical success

    During procedure

  • Primary and secondary patency rate

    12 months

  • Ankle-Brachial Index improvement of ≥ 0.1

    1, 6 and 12 months

  • Clinically driven target vessel revascularization

    6 and 12 months

  • +2 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with documented symptomatic occlusion and/or \> 70% stenosis of SFA.

You may qualify if:

  • Patients with symptomatic leg ischemia requiring treatment of SFA artery or proximal popliteal artery located within the following parameters:
  • cm from the femoral bifurcation in the SFA
  • cm from the proximal margin of the intercondylar fossa
  • Rutherford-Becker Category 2-5. In patients with bilateral lesions, the highest Rutherford Category limb should be treated. Only 1 leg can be included.
  • Single lesion which can be covered by one stent.
  • Target vessel reference diameter ≥ 4 mm and ≤ 6 mm (by visual estimate)
  • A patent popliteal artery free from significant stenosis (\>50%) with at least one patent vessel runoff as confirmed by baseline angiography
  • Signed informed consent.

You may not qualify if:

  • Pregnancy
  • Previous stenting of target lesion
  • Acute ischemia
  • Significant gastrointestinal bleeding or any coagulopathy that would contraindicate the use of anti-platelet therapy
  • Known intolerance to study medications or contrast agents.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Ghent

Ghent, Belgium

Location

MeSH Terms

Conditions

Peripheral Arterial Disease

Condition Hierarchy (Ancestors)

AtherosclerosisArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesPeripheral Vascular Diseases

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

August 16, 2011

First Posted

August 19, 2011

Study Start

January 1, 2011

Primary Completion

September 1, 2014

Study Completion

September 1, 2014

Last Updated

July 16, 2015

Record last verified: 2015-07

Locations