NCT01412398

Brief Summary

This study is a regulatory post marketing surveillance in Japan, and it is a local prospective and observational study of patients in continuous ambulatory peritoneal dialysis (CAPD) who have received Fosrenol for hyperphosphatemia. The objective of this study is to assess safety and efficacy of using Fosrenol in clinical practice. This study is also all case investigation of which the enrollment period is one year, and all patients in CAPD who received Fosrenol for hyperphosphatemia will be recruited and followed one year.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
446

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2009

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 7, 2009

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

August 4, 2011

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 9, 2011

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 8, 2014

Completed
2.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2016

Completed
Last Updated

January 19, 2018

Status Verified

January 1, 2018

Enrollment Period

5 years

First QC Date

August 4, 2011

Last Update Submit

January 18, 2018

Conditions

Keywords

FosrenolHyperphosphatemiaContinuous Cyclic Peritoneal Dialysis

Outcome Measures

Primary Outcomes (2)

  • Incidence of adverse drug reactions in subjects who received Fosrenol

    After Fosrenol administration, up to 1 year

  • Incidence of serious adverse events in subjects who received Fosrenol

    After Fosrenol administration, up to 1 year

Secondary Outcomes (4)

  • Incidence of adverse drug reactions in subpopulation with baseline data [such as demographic data, concomitant disease, duration of treatment, maximum daily dose] and dose of Fosrenol

    After Fosrenol administration, up to 1 year

  • Effectiveness evaluation assessment [achievement rate of a goal phosphate level; 3.5-6 mg/dL]

    After Fosrenol administration, up to 1 year

  • Effectiveness evaluation assessment [achievement rate of a goal calcium level; 8.4-10.0 mg/dL]

    After Fosrenol administration, up to 1 year

  • Clinical test value collections [calciotropic hormones, bone turnover markers]

    After Fosrenol administration, up to 1 year

Study Arms (1)

Group 1

Drug (incl. Placebo)

Drug: Lanthanum Carbonate (Fosrenol, BAY77-1931) - chewable tablet

Interventions

Patients in CAPD who have received Fosrenol for hyperphosphatemia

Group 1

Eligibility Criteria

Age13 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

This study is all case investigation of which the enrollment period is one year, and all patients in CAPD who received Fosrenol for hyperphosphatemia will be recruited.

You may qualify if:

  • Patients undergoing continuous ambulatory peritoneal dialysis who received Fosrenol for hyperphosphatemia

You may not qualify if:

  • Patients who are contraindicated based on the product label

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Unknown Facility

Multiple Locations, Japan

Location

MeSH Terms

Conditions

Hyperphosphatemia

Interventions

lanthanum carbonate

Condition Hierarchy (Ancestors)

Phosphorus Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Bayer Study Director

    Bayer

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 4, 2011

First Posted

August 9, 2011

Study Start

April 7, 2009

Primary Completion

April 8, 2014

Study Completion

September 1, 2016

Last Updated

January 19, 2018

Record last verified: 2018-01

Locations