NCT01403220|Completed
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Sponsor study identifier
Secondary identifiers
OTHER · ANSM
interventional
163
1 country
1
Study Start
April 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 17, 2015
Actual (reported)Study Completion
March 17, 2015
Actual (reported)The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 17, 2015
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 25, 2011
Actual (reported)July 27, 2011
Actual (reported)April 2012
Date type not reportedThis date has not been verified as actual or estimated.
March 17, 2015
Actual (reported)March 17, 2015
Actual (reported)Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.
Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration.
12 hours
Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%.
24 hours
Urea clearance (ml/min) for the dialysis sequence under study
12 hours
Filter lifespan (hours) for the dialysis sequence under study.
12 hours.
The percentage down-time for the first 24 hours of dialysis
24 hours
Fluid replacement (yes/no)
12 hours
This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.
This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.
Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.
Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.
Centre Hospitalier Universitaire de Nîmes
Nîmes, Gard, 30029, France
Roger C, Muller L, Wallis SC, Louart B, Saissi G, Lipman J, Lefrant JY, Roberts JA. Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration. J Antimicrob Chemother. 2016 Feb;71(2):464-70. doi: 10.1093/jac/dkv349. Epub 2015 Nov 3.
Roger C, Wallis SC, Muller L, Saissi G, Lipman J, Bruggemann RJ, Lefrant JY, Roberts JA. Caspofungin Population Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-Venous Haemofiltration or Haemodiafiltration. Clin Pharmacokinet. 2017 Sep;56(9):1057-1068. doi: 10.1007/s40262-016-0495-z.
Pascal Jeannes, MD
Centre Hospitalier Universitaire de Nīmes
163 participants (actual enrollment reported by the registry).
First Submitted
July 25, 2011
First Posted
July 27, 2011
Study Start
April 2012
Date type not reportedThis date has not been verified as actual or estimated.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Roger C, Wallis SC, Muller L, Saissi G, Lipman J, Lefrant JY, Roberts JA. Influence of Renal Replacement Modalities on Amikacin Population Pharmacokinetics in Critically Ill Patients on Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4901-9. doi: 10.1128/AAC.00828-16. Print 2016 Aug.
Primary Completion
March 17, 2015
Actual (reported)Study Completion
March 17, 2015
Actual (reported)Last Updated
November 17, 2025
Record last verified: 2015-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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