Cranberry Enhances Human Immune Function and Reduces Illness

NCT01398150 | Completed

• 1 other identifier: CB-79545
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether consuming a beverage made with cranberry polyphenols and proanthocyanidins is effective in modifying immune function by enhancing immune cell proliferation, cytokine production, and antioxidant capacity. If immune cell proliferation is improved, the subjects are expected to have fewer cold and flu symptoms.

Conditions

Healthy Humans

Keywords

gamma delta T cell; proliferation; cytokine secretion; immune function; antioxidant status

Outcome Measures

Primary Outcomes (1)

• Physiological modifications to immune cell function

  Proliferation of γδ-T cells when cultured ex vivo in autologous serum

  70 days

Secondary Outcomes (2)

• Cold and flu symptoms

  70 days

• Anti-inflammatory outcome

  70 days

Study Arms (2)

Sweetened Beverage

PLACEBO COMPARATOR

looks like and is given in the same way as the experimental treatment but contains no active ingredient

Dietary Supplement: Beverage made to look like the cranberry beverage

Cranberry Beverage

EXPERIMENTAL

15 ounce bottle of cranberry beverage consumed daily for 70 days

Dietary Supplement: Beverage made from cranberry compounds

Interventions

Beverage made to look like the cranberry beverage DIETARY_SUPPLEMENT

one 15 ounce bottle of beverage consumed daily

Sweetened Beverage

Beverage made from cranberry compounds DIETARY_SUPPLEMENT

one 15 ounce bottle consumed daily for 70 days

Cranberry Beverage

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Health male or non-pregnant female
• Between the ages of 21 and 50
• BMI between 18 and 35

You may not qualify if:

• High blood pressure define as 140/90
• Ongoing or chronic illness or infection
• On hypertensive medication, immunosuppressive drugs, antibiotics, or chronic use of NSAIDS
• Taking plant-based dietary supplements, antioxidant supplements, or probiotics
• Vegetarian or strict vegan
• Consume more than 1 cup of tea (iced or hot) per day
• Consumes more than 2 glasses of alcoholic beverages per day
• Consume more than 7 fruits and vegetables per day

Sponsors & Collaborators

• University of Florida: lead
• Ocean Spray, Inc.: collaborator

Study Sites (1)

449 Food Science and Human Nutrition Department

Gainesville, Florida, 32611, United States

Location

Related Publications (1)

• Nantz MP, Rowe CA, Muller C, Creasy R, Colee J, Khoo C, Percival SS. Consumption of cranberry polyphenols enhances human gammadelta-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study. Nutr J. 2013 Dec 13;12:161. doi: 10.1186/1475-2891-12-161.

  PMID: 24330619 DERIVED

Study Officials

• Susan S Percival, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2011
• First Posted: July 20, 2011
• Study Start: March 1, 2009
• Primary Completion: May 1, 2009
• Study Completion: May 1, 2009
• Last Updated: September 20, 2011

Record last verified: 2010-02

Locations

US (1)