Microcirculation During Haemodialysis
Sublingual Microcirculatory Flow Measurements During Haemodialysis in Relation to Blood Volume Change
1 other identifier
observational
8
1 country
1
Brief Summary
- SDF is validated by measuring changes in microcirculation in sepsis patients with MOF (Boerma studies).
- SDF is validated by measuring changes in microcirculation in stable chronic hemodialysis patients (NDT 2009 Bemelmans).
- Ultrafiltration in stable chronic hemodialysis leads to a decrease in sublingual microcirculatory flow (NDT 2009 Bemelmans).
- Trendelenburg position improves the sublingual microcirculatory flow at the end of hemodialysis treatment (NDT 2009 Bemelmans).
- Hemodialysis with ultrafiltration leads to a significant reduction of myocardial perfusion and cardiac output (NDT 2009 Dasselaar)
- Cardiac output measurement during dialysis is not practical.
- BVM is a validated method for hypotension due to ultrafiltration to prevent the amount of ultrafiltration online change based on the measured haemoconcentration (ref Dasselaar et al NDT 2005).
- BCM is a validated measurement to the dry weight in hemodialysis patients measured by a bioimpedance technique (NDT Passauer et al 2009).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2011
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 31, 2011
CompletedFirst Posted
Study publicly available on registry
July 19, 2011
CompletedStudy Start
First participant enrolled
September 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedFebruary 22, 2012
February 1, 2012
4 months
May 31, 2011
February 20, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Difference between sublingual microvascular flow index between 2 types of ultrafiltration
3 weeks
Study Arms (1)
dialysis patients
dialysis patients, stabil, dialysis dependancy for more than 3 months, with adequate access
Eligibility Criteria
Stable hemodialysis patients with dialysis dependancy for more than 3 months, with adequate access
You may qualify if:
- dialysis patient
- age \> 18
- informed consent
You may not qualify if:
- no adequate access
- instable hemodynamics
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical Centre Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Related Publications (1)
Veenstra G, Pranskunas A, Skarupskiene I, Pilvinis V, Hemmelder MH, Ince C, Boerma EC. Ultrafiltration rate is an important determinant of microcirculatory alterations during chronic renal replacement therapy. BMC Nephrol. 2017 Feb 20;18(1):71. doi: 10.1186/s12882-017-0483-z.
PMID: 28219329DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Christiaan Boerma, MD
Frisius Medisch Centrum
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
May 31, 2011
First Posted
July 19, 2011
Study Start
September 1, 2011
Primary Completion
January 1, 2012
Study Completion
February 1, 2012
Last Updated
February 22, 2012
Record last verified: 2012-02