Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients

NCT01391416 | Completed DMC

• 1 other identifier: VJR-0002
• Study Type: observational
• Target: 98
• Locations: 0 countries
• Sites: N/A

Brief Summary

It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.

Conditions

Cardiovascular Disease; Hyperhomocysteinemia

Keywords

Hyperhomocysteinemia; Chronic kidney disease

Outcome Measures

Primary Outcomes (1)

• Level of Homocysteine

  Level of homocysteinemia according to each CKD level

  3 months

Secondary Outcomes (1)

• Association of cardiovascular event to the level of homocysteine

  3 months

Study Arms (2)

CKD stage 3-4

CKD stage 3-4 from Thai SEEK study

hyperhomocysteine group

CKD stage 3-4 from Thai SEEK study

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Ninety eight subjects from CKD stages 3-4 were randomly sampling from Thai- SEEK study database. Thai-SEEK study is a community-based cross-sectional survey that was conducted between August 2007-june 2008 in four regions of Thailand (i.e Northern, Northeastern, Central and Southern) and Bangkok (Metropolitan).

You may qualify if:

• CKD stages 3-4 from Thai SEEK Study

You may not qualify if:

• CKD stage 5

Sponsors & Collaborators

• Bangkok Metropolitan Administration Medical College and Vajira Hospital: lead

Related Publications (1)

• Ingsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P, Gojaseni P, Kiattisunthorn K, Ongaiyooth L, Vanavanan S, Sirivongs D, Thirakhupt P, Mittal B, Singh AK; Thai-SEEK Group. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant. 2010 May;25(5):1567-75. doi: 10.1093/ndt/gfp669. Epub 2009 Dec 27.

  PMID: 20037182 BACKGROUND

Related Links

• Research Subcommite

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Cardiovascular Diseases; Hyperhomocysteinemia; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Amino Acid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Malabsorption Syndromes; Metabolic Diseases; Nutritional and Metabolic Diseases; Vitamin B Deficiency; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Thananda Trakarnvanich, M.D.

  Renal Unit,Department of Medicine,Faculty of Medicine,Vajira Hospital,University of Bangkok Metropolis

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: July 8, 2011
• First Posted: July 12, 2011
• Study Start: June 1, 2010
• Primary Completion: November 1, 2010
• Study Completion: January 1, 2011
• Last Updated: July 12, 2011

Record last verified: 2010-05