Determination of ED50 and ED95 of Vecuronium Infusion Dose for Maintaining Response of Train of Four Less Than 2 During the MEP Monitoring for Neurosurgery
Sponsor study identifier
interventional
90
1 country
1
Study Start
June 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2012
Actual (reported)Study Completion
February 2012
Actual (reported)The maintenance of partial neuromuscular blocking during general anesthesia for neurosurgery is essential for intraoperative motor-evoked potential monitoring. However, the precise strategy of administering neuromuscular blocking agent for obtaining that goal has not been established. Therefore, the investigators tried to find the optimal initial dose of vecuronium infusion and determine the adequate goal of neuromuscular blocking as guided by neuromuscular transmission module (M-NMT Module, Datex-Ohmeda Inc, Helsinki, Finland).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2012
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2011
Date type not reportedThis date has not been verified as actual or estimated.
June 28, 2011
Actual (reported)July 7, 2011
Actual (reported)February 2012
Actual (reported)February 2012
Actual (reported)Amplitude of MEP monitoring
the value of MEP amplitude every 30 min during MEP monitoring
every 30 min during MEP monitoring
latency of MEP monitoring
every 30 min during MEP monitoring
Incidence of patient's spontaneous movement
from start to end of the MEP monitoring, an expected average of 4 hours
Overall assessment of MEP monitoring quality
from start to end of the MEP monitoring, an expected average of 4 hours
Incidence of patient's spontaneous respiration
from start to end of the MEP monitoring, an expected average of 4 hours
adjustment of neuromuscular blocking agent infusion dose every 15 minute as guided by No. of response to TOF stimulation
adjustment of neuromuscular blocking agent infusion dose every 15 minute as guided by T1 twitch height as compared with control (T0)
adjustment of neuromuscular blocking agent infusion dose every 15 minute as guided by T2 twitch height as compared with baseline (T0)
adjustment of vecuronium infusion dose every 15 minutes as guided by No. of response to TOF stimulation displayed by NMT module.
adjustment of vecuronium infusion dose every 15 minutes as guided by T1 twitch height as compared with baseline (T0) displayed by NMT module.
Jeong Jin Lee
Seoul, 135-710, South Korea
Jeong Jin Lee, M.D.,Ph.D.
Samsung Medical Center
Won Ho Kim, M.D.
Samsung Medical Center
90 participants (actual enrollment reported by the registry).
First Submitted
June 28, 2011
First Posted
July 7, 2011
Study Start
June 2011
Date type not reportedThis date has not been verified as actual or estimated.
adjustment of vecuronium infusion dose every 15 minutes as guided by T2 twitch height as compared with baseline (T0)displayed by NMT module.
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Primary Completion
February 2012
Actual (reported)Study Completion
February 2012
Actual (reported)Last Updated
May 15, 2012
Record last verified: 2012-05
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