Using Impression Cytology to Observe the Cytological Changes of Ocular Surface Cells in Various Ocular Surface Disorders

NCT01387971 | Unknown

• 1 other identifier: 200910001R
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Currently, due to the advantage of noninvasive, localized, rapid, painless and easily repeatable of impression specimens, the technique is an ideal method of investigating ocular surface disorders when the diagnosis is not clinically obvious or detecting the post-operative change without tissue damage. Using impression cytology for primary diagnosis and follow-up of ocular surface squamous neoplasia, including after therapy with topical mitomycin C has been well-studied. \[29\]. In addition to the applications described above, pterygium is another disease of interest. Pterygium, a common disease of ocular surface, has high recurrence rate after surgical excision. \[30-33\] However, the exact etiology and mechanism for recurrence is unknown. A transformation of the phenotypic characteristics of the conjunctival fibroblasts may play an important role. Due to the concern of improvement in treatment, it is important to explore the change of cytomorphology after pterygium operation, to identify the risk factors of developing recurrence, and, furthermore, to clarify the etiology and mechanism. Some ophthalmologists may think this procedure too time-consuming to be a routine examination in outpatient clinics. \[34\] However, National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in Taiwan, is now in charge of a big part of difficult cases of ocular surface. With the need of further precise diagnosis and delicate clinical skills, the investigators are competent for this meaningful program.

Conditions

Pterygium; Dry Eye; Tumor

Keywords

impression cytology; ocular surface disorders; ocular surface cells' variation; Limbal insufficiency

Study Arms (1)

ocular surface disorders

various ocular surface disorders

Eligibility Criteria

• Age: 12 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

various ocular surface disorders

You may qualify if:

• various ocular surface disorders

You may not qualify if:

• cognitive function disorder
• extremely ocular surface discomfort

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital, department of Ophthalmology

Taipei, Taiwan, Taiwan

RECRUITING

MeSH Terms

Conditions

Pterygium; Dry Eye Syndromes; Neoplasms

Condition Hierarchy (Ancestors)

Conjunctival Diseases; Eye Diseases; Lacrimal Apparatus Diseases

Study Officials

• Wei-Li Chen, PhD

  National Taiwan University Hospital, department of Ophthalmology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wei-Li Chen, MD

CONTACT

886-2-23123456; chenweili@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 1, 2011
• First Posted: July 6, 2011
• Study Start: September 1, 2009
• Primary Completion: August 1, 2012
• Study Completion: August 1, 2012
• Last Updated: July 6, 2011

Record last verified: 2011-04

Locations

TW (1)