The Role of Genital Warts in HIV Acquisition in Peru

NCT01387412 | Completed

• 1 other identifier: Merck IISP 39619
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to determine the role of genital warts (GW) on Human Immunodeficiency Virus (HIV) acquisition among men who have sex with men (MSM) in Peru. The secondary objectives are to determine Human Papillomavirus (HPV) prevalence in HIV positive MSM in Peru, risk factors associated with GW, and the knowledge of HPV and HIV among MSM.

Conditions

Anogenital Warts; HIV

Keywords

genital warts; HIV; MSM; Peru; HPV

Outcome Measures

Primary Outcomes (1)

• HIV incidence

  new cases of HIV in our cohort in either the group with or without genital warts

  2 years

Study Arms (1)

Genital warts

Those with and without ano-genital warts

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Community sample

You may qualify if:

• Anatomical males 18-40 years of age,
• Self-reported anal sex with another man within 12 months prior to enrollment,
• Willing to provide informed consent for the collection of demographic and sexual behavior data, as well as blood for HIV and Syphilis testing, swabs of anal mucosa for HPV testing and urine for Chlamydia testing,
• Resident of metropolitan Lima.

You may not qualify if:

• Prior participation in an HPV vaccine clinical trial,
• Prior participation in an HIV vaccine clinical trial,
• Presence of a known immunodeficiency that increases risk of acquiring HIV.

Sponsors & Collaborators

• University of California, Los Angeles: lead
• Espacio Comun: collaborator
• Universidad Peruana Cayetano Heredia: collaborator

Study Sites (1)

Espacio Comun

Barranco, Lima region, Peru

Location

Related Publications (13)

• Smith JS, Moses S, Hudgens MG, Parker CB, Agot K, Maclean I, Ndinya-Achola JO, Snijders PJ, Meijer CJ, Bailey RC. Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection. J Infect Dis. 2010 Jun 1;201(11):1677-85. doi: 10.1086/652408.

  PMID: 20415595 BACKGROUND

• Jin F, Prestage GP, Imrie J, Kippax SC, Donovan B, Templeton DJ, Cunningham A, Mindel A, Cunningham PH, Kaldor JM, Grulich AE. Anal sexually transmitted infections and risk of HIV infection in homosexual men. J Acquir Immune Defic Syndr. 2010 Jan;53(1):144-9. doi: 10.1097/QAI.0b013e3181b48f33.

  PMID: 19734801 BACKGROUND

• Caceres CF, Mendoza W. Monitoring trends in sexual behaviour and HIV/STIs in Peru: are available data sufficient? Sex Transm Infect. 2004 Dec;80 Suppl 2(Suppl 2):ii80-4. doi: 10.1136/sti.2004.012021.

  PMID: 15572646 BACKGROUND

• Bautista CT, Sanchez JL, Montano SM, Laguna-Torres VA, Lama JR, Sanchez JL, Kusunoki L, Manrique H, Acosta J, Montoya O, Tambare AM, Avila MM, Vinoles J, Aguayo N, Olson JG, Carr JK. Seroprevalence of and risk factors for HIV-1 infection among South American men who have sex with men. Sex Transm Infect. 2004 Dec;80(6):498-504. doi: 10.1136/sti.2004.013094.

  PMID: 15572623 BACKGROUND

• Clark JL, Segura ER, Montano SM, Leon SR, Kochel T, Salvatierra HJ, Alcantara J, Caceres CF, Coates TJ, Klausner JD. Routine laboratory screening for acute and recent HIV infection in Lima, Peru. Sex Transm Infect. 2010 Dec;86(7):545-7. doi: 10.1136/sti.2010.042697.

  PMID: 21113069 BACKGROUND

• Goldstone S, Palefsky JM, Giuliano AR, Moreira ED Jr, Aranda C, Jessen H, Hillman RJ, Ferris DG, Coutlee F, Liaw KL, Marshall JB, Zhang X, Vuocolo S, Barr E, Haupt RM, Guris D, Garner EI. Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. J Infect Dis. 2011 Jan 1;203(1):66-74. doi: 10.1093/infdis/jiq016.

  PMID: 21148498 BACKGROUND

• Li AH, Phanuphak N, Sahasrabuddhe VV, Chaithongwongwatthana S, Vermund SH, Jenkins CA, Shepherd BE, Teeratakulpisarn N, van der Lugt J, Avihingsanon A, Ruxrungtham K, Shikuma C, Phanuphak P, Ananworanich J. Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand. Sex Transm Infect. 2009 Dec;85(7):503-7. doi: 10.1136/sti.2009.036707. Epub 2009 Jun 11.

  PMID: 19525263 BACKGROUND

• Cohen MS. Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis. Lancet. 1998;351 Suppl 3:5-7. doi: 10.1016/s0140-6736(98)90002-2. No abstract available.

  PMID: 9652712 BACKGROUND

• Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999 Feb;75(1):3-17. doi: 10.1136/sti.75.1.3.

  PMID: 10448335 BACKGROUND

• Grosskurth H, Mosha F, Todd J, Mwijarubi E, Klokke A, Senkoro K, Mayaud P, Changalucha J, Nicoll A, ka-Gina G, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet. 1995 Aug 26;346(8974):530-6. doi: 10.1016/s0140-6736(95)91380-7.

  PMID: 7658778 BACKGROUND

• Flores JA, Brown B, Leon SR, Sanchez H, Galea JT. Individual-level characteristics associated with oral HIV test acceptability among Peruvian men who have sex with men and transgender women: a cross-sectional study. Sex Transm Infect. 2018 Nov;94(7):528-533. doi: 10.1136/sextrans-2017-053388. Epub 2018 Mar 24.

  PMID: 29574465 DERIVED

• Galea JT, Leon SR, Peinado J, Calvo G, Zamora J, Sanchez H, Brown BJ. HPV knowledge, burden and genital wart location among heterosexually identified versus homosexually identified men who have sex with men in Lima, Peru: cross-sectional results from a cohort study. BMJ Open. 2017 Oct 24;7(10):e017338. doi: 10.1136/bmjopen-2017-017338.

  PMID: 29070638 DERIVED

• Brown B, Davtyan M, Leon SR, Sanchez H, Calvo G, Klausner JD, Galea J. A prospective cohort study characterising the role of anogenital warts in HIV acquisition among men who have sex with men: a study protocol. BMJ Open. 2014 Sep 16;4(9):e005687. doi: 10.1136/bmjopen-2014-005687.

  PMID: 25227629 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

serum, lesion biopsies

MeSH Terms

Conditions

Condylomata Acuminata

Condition Hierarchy (Ancestors)

Papillomavirus Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Communicable Diseases; Infections; DNA Virus Infections; Virus Diseases; Warts; Skin Diseases, Viral; Tumor Virus Infections; Genital Diseases; Urogenital Diseases; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Brandon Brown, PhD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

• Jerome Galea, MSW

  Espacio Comun

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Faculty

Study Record Dates

• First Submitted: June 30, 2011
• First Posted: July 4, 2011
• Study Start: April 1, 2012
• Primary Completion: September 1, 2015
• Study Completion: September 1, 2015
• Last Updated: December 2, 2015

Record last verified: 2015-11

Locations

PE (1)