The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

NCT01384136 | Unknown DMC

• 1 other identifier: 036-2011 MMC
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress. The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes. The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Conditions

Telomere Length; Mechanisms of Telomter Homeostasis; High Risk Pregnancies

Study Arms (2)

High risk pregnancy

|Control - Normal low risk pregnancies

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

High risk pregnancies, third trimester, after the delivery/

You may qualify if:

• Third trimester post delivery
• Intrauterine growth restriction
• Preeclampsia
• Diabetes
• Control - low risk normal pregnancies

You may not qualify if:

• Patients who do not want to participate
• Known HIV or Hepatitis

Sponsors & Collaborators

• Meir Medical Center: lead

Study Sites (1)

Meir Medical Center

Kfar Saba, Israel

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 27, 2011
• First Posted: June 28, 2011
• Study Start: June 1, 2011
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: June 28, 2011

Record last verified: 2011-06

Locations

IL (1)