Trials Sponsors Conditions Drugs Pricing

Conditions

Unilateral Limbal Stem Cell Insufficiency

Keywords

limbal stem cellamniotic membraneex vivo expansion of autologous limbal stem cellunilateral limbal stem cell insufficiency

Outcome Measures

Primary Outcomes (1)

The extent of corneal epithelium regeneration
one week, two week, one month, two months, three months, six months and one year later

Secondary Outcomes (2)

visual acuity
one week, two week, one month, two months, three months, six months and one year later
complications
one week, two week, one month, two months, three months, six months and one year later

Study Arms (1)

1

EXPERIMENTAL

Patients suffering from unilateral limbal stem cell insufficiency. Remove the abnormal surface tissue on the lesion cornea, transplant the amniotic membrane with cultured limbal stem cells on the denuded cornea. Cover with contact lens after operation, and apply topical antibiotics and steroids.

Procedure: Transplant of cultured limbal stem cells on cornea

Interventions

Transplant of cultured limbal stem cells on corneaProcedure

Remove the abnormal surface tissue on the lesion cornea, transplant the amniotic membrane with cultured limbal stem cells on the denuded cornea. Cover with contact lens after operation, and apply topical antibiotics and steroids.

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Sexall

Healthy VolunteersNo

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

unilateral limbus defect larger than 180 degrees
repeated corneal epithelial ulcer, loss of visual acuity or neovascularization due to limbal stem cell insufficiency

Sponsors & Collaborators

National Taiwan University Hospital
Otherlead

Study Sites (1)

National Taiwan University Hospital, department of Ophthalmology

Taipei, 10047, Taiwan

Study Officials

Wei-Li Chen, MD, PhD
National Taiwan University Hospital, department of Ophthalmology
PRINCIPAL INVESTIGATOR

Enrollment

0 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 1
Allocation: NON RANDOMIZED
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER

Study Record Dates

First Submitted

April 21, 2011

First Posted

June 21, 2011

Study Start

July 2008

Date type not reported

This date has not been verified as actual or estimated.

Study Stopped

The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

1

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

1

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations