The Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke

NCT01376609 | Unknown

• 1 other identifier: BUCM-002H-ND
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Previous research has shown there wasn't inevitable relationship between mismatch area and infarct growth according to Volumetric-subtraction mismatch volume.The recently published on Stroke paper has proposed Coregistration mismatch to calculate the mismatch to replace ischaemic penumbra, and it reignites hope for clinical application of the PWI/DWI mismatch. But the correlation between the mismatch, calculated by Coregistration mismatch method,and the clinical outcome of the patients with acute ischemic stroke is still unknown. so the investigators plan to conduct a prospective observational cohort study.

Conditions

Ischemic Stroke

Keywords

Stroke; Ischaemic Stroke; Cerebral Infarction; Cerebrovascular Disorders; Brain Diseases; Nervous System Diseases; Vascular Diseases; Brain Infarction; Brain Ischemia; mismatch; PWI/DWI mismatch; ischaemic penumbra; image analysis

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with acute ischaemic stroke admitted to ASU.

You may qualify if:

• Aged eighteen or above
• Acute middle cerebral artery ischemic stroke
• Stroke onset within 48 hours
• Included a complete set of initial MR images and final outcome MR images up to 1 months

You may not qualify if:

• History of stroke in the past 6 weeks
• Pre-existing neurological or psychiatric disease that could confound the study results such as a pre-stroke mRS score greater than 3
• CT evidence of the following conditions before enrollment:
• Significant mass effect with midline shift Evidence of intracranial hemorrhage
• With contraindication to MR such as severe allergy to contrast media

Sponsors & Collaborators

• Beijing Hospital of Traditional Chinese Medicine: lead
• Beijing University of Chinese Medicine: collaborator

Study Sites (1)

Jianghai Ruan

Beijing, Beijing Municipality, 100078, China

Location

MeSH Terms

Conditions

Ischemic Stroke; Stroke; Cerebral Infarction; Cerebrovascular Disorders; Brain Diseases; Nervous System Diseases; Vascular Diseases; Brain Infarction; Brain Ischemia

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 17, 2011
• First Posted: June 20, 2011
• Study Start: August 1, 2011
• Primary Completion: March 1, 2012
• Study Completion: August 1, 2013
• Last Updated: August 1, 2011

Record last verified: 2011-06

Locations

CN (1)