Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
dARICUPEEP
Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure
1 other identifier
observational
20
1 country
1
Brief Summary
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jan 2011
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedFirst Submitted
Initial submission to the registry
June 14, 2011
CompletedFirst Posted
Study publicly available on registry
June 20, 2011
CompletedJune 22, 2020
June 1, 2020
5 months
June 14, 2011
June 19, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Integrity of the cerebrovascular autoregulation (CA)
Cerebrovascular autoregulation will be calculated as a moving correlation index (Mx) from the cerebral blood flow velocity and the arterial blood pressure. It is a parameter without unit (index).
30 Minutes
Study Arms (1)
respiratory failure
patients with respiratory failure and need of high positive end-expiratory pressure ventilation.
Interventions
Elevation of positive end-expiratory failure for recruitment
Eligibility Criteria
Adult patients on intensive care unit with acute respiratory failure
You may qualify if:
- respiratory failure
- Age \>18 years
- Invasive ventilation
You may not qualify if:
- Sepsis
- preexisting cerebral illness
- traumatic brain injury
- meningitis or encephalitis
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University medical centre
Mainz, 55131, Germany
Related Publications (1)
Schramm P, Closhen D, Felkel M, Berres M, Klein KU, David M, Werner C, Engelhard K. Influence of PEEP on cerebral blood flow and cerebrovascular autoregulation in patients with acute respiratory distress syndrome. J Neurosurg Anesthesiol. 2013 Apr;25(2):162-7. doi: 10.1097/ANA.0b013e31827c2f46.
PMID: 23211642RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Patrick Schramm, MD
Department of Anesthesiology, University medicine Mainz, Germany
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Physician
Study Record Dates
First Submitted
June 14, 2011
First Posted
June 20, 2011
Study Start
January 1, 2011
Primary Completion
June 1, 2011
Study Completion
June 1, 2011
Last Updated
June 22, 2020
Record last verified: 2020-06