Acceptability and Effectiveness of Household Water Treatment in Reducing Diarrhea Among Under Five Children

NCT01376440 | Completed Phase 1 DMC

• 1 other identifier: SGS13/15/11
• Study Type: interventional
• Target: 845
• Locations: 1 country
• Sites: 1

Brief Summary

The Millenium development goals (MDGs) call for reducing by half the proportion of people without sustainable access to safe drinking water. This goal was adopted in large part because safe drinking water has been seen as critical to fighting diarrheal disease. Source protection is considered the main intervention area to achieve this goal. However, research worldwide that has shown that even drinking water which is safe at the source is subject to frequent and extensive fecal contamination during collection, storage and use in the home. This contamination is through the introduction of cups, dippers or hands, contamination by flies, cockroaches, and rats. Even piped water supplies of adequate microbial quality can pose infectious disease risks if they become contaminated due to unsanitary collection, storage conditions and practices within households. To reduce this problem, point-of-use water treatment has been advocated as a means to substantially decrease the global burden of diarrhea and to contribute to the MDGs. However, research indicates that there are many unanswered questions around Household water treatment (HWT) that require small or medium scale epidemiological studies and randomized controlled trials, especially with regard to effectiveness, acceptability and identifying suitable target populations. Some of the most urgent questions to be resolved are:(1) How much of the currently cited disease reduction of HWT is due to bias? (2) What is the effect of HWT on nutritional status (weight gain and growth)?(3) At which populations should HWT be targeted? (4) Is it acceptable and sustainable in poor communities where the risk of diarrheal disease is high. hypothesis: Do household water treatment with chlorine reduce diarrhea among underfive children? hypothesis: Do household water treatment with chlorine acceptable in the community?

Conditions

Acute Diarrhoea

Keywords

three or more loss stools in 24 hours

Outcome Measures

Primary Outcomes (1)

• To assess the prevalence of diarrhea among under five children

  weekly visit of the household for the presence of diarrhoea among underfive for four months in both the intervention and control groups

  four months

Secondary Outcomes (2)

• To assess the weight gain among the intervention and control groups of under five children

  At the beginning and end of the study ( 4 months interval)

• Residual chlorine test

  four months

Study Arms (2)

Household water treatment

EXPERIMENTAL

household water treatment with 1.25% sodium hypochlorite

Other: household water treatment

control

NO INTERVENTION

Usual practice (the use of "Jerrican" for water storage, which is considered as safe storage)

Interventions

household water treatment OTHER

household water treatment with 1.25% sodium hypochlorite

Also known as: 1.25% sodium hypochlorite

Household water treatment

Eligibility Criteria

• Age: 1 Month - 59 Months
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• All children under five years of age in the randomly selected clusters of Kersa district

You may not qualify if:

• seriously sick children in the randomly selected clusters of Kersa district

Sponsors & Collaborators

• Haramaya Unversity: lead

Study Sites (1)

Kersa district

Kersa, Eastern Hararage, 235, Ethiopia

Location

Related Publications (1)

• Mengistie B, Berhane Y, Worku A. Household water chlorination reduces incidence of diarrhea among under-five children in rural Ethiopia: a cluster randomized controlled trial. PLoS One. 2013 Oct 23;8(10):e77887. doi: 10.1371/journal.pone.0077887. eCollection 2013.

  PMID: 24194899 DERIVED

MeSH Terms

Interventions

Sodium Hypochlorite

Intervention Hierarchy (Ancestors)

Hypochlorous Acid; Chlorine Compounds; Inorganic Chemicals; Oxides; Oxygen Compounds; Sodium Compounds

Study Officials

• Bezatu M Alemu, M.Sc

  Assistant professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Mr

Study Record Dates

• First Submitted: June 16, 2011
• First Posted: June 20, 2011
• Study Start: June 1, 2011
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2011
• Last Updated: January 24, 2012

Record last verified: 2012-01

Locations

ET (1)