Deep Brain Stimulation (DBS) for Treatment Resistant Bipolar Disorder

NCT01372722 | Withdrawn Phase 2

• 1 other identifier: BSG-11-4712DBS
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Hypothesis to be tested: Bilateral Deep Brain Stimulation to the Nucleus Accumbens is associated with clinically and statistically significant improvement in patients with treatment resistant bipolar disorder. Overall Objective: The aim in this interdisciplinary, psychiatric-neurosurgical project is to evaluate safety and efficacy of bilateral Deep Brain Stimulation to the Nucleus Accumbens (NAcc) using the Medtronic Activa RC Neurostimulator in patients with treatment resistant Bipolar Disorder.

Conditions

Bipolar Disorder

Keywords

treatment resistant

Outcome Measures

Primary Outcomes (2)

• Depression Severity rated with Montgomery Asberg Depression Scale (MADRS)

  The Montgomery-Åsberg Depression Rating Scale (abbreviated MADRS) is a ten-item diagnostic questionnaire which psychiatrists use to measure the severity of depressive episodes in patients with mood disorders. It was designed in 1979 by British and Swedish researchers as an adjunct to the Hamilton Rating Scale for Depression (HAMD) which would be more sensitive to the changes brought on by antidepressants and other forms of treatment than the Hamilton Scale is.

  12 month after DBS stimulation onset

• Young Mania Rating Scale (YMRS)

  One of the most frequently used rating scales to assess manic symptoms. The scale has 11 items and is based on the patient's subjective report of his or her clinical condition over the previous 48 hours. This scale will be used to assess the development of manic symptoms over time, mainly in order to assess treatment emergent manic symptoms.

  12 month after DBS stimulation onset

Secondary Outcomes (3)

• Depression Severity rated with Hamilton Depression Rating Scale (HDRS24)

  12 month after DBS stimulation onset

• Adverse Event Schedule

  12 month after DBS stimulation onset

• Comprehensive neuropsychological test battery

  12 month after DBS stimulation onset

Study Arms (2)

Sham then Stimulation

EXPERIMENTAL

Device: DBS Activa PC systems Medtronic

Stimulation then Sham

EXPERIMENTAL

Device: DBS, Activa PC systems Medtronic

Interventions

DBS, Activa PC systems Medtronic DEVICE

30Hz, 90us pulsewidth, 4V Amplitude

Stimulation then Sham

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 20-70 years old. • German mother tongue • Ability to provide written informed consent.
• At least one manic or hypomanic episode according to DSM IV previous to onset of last depressive episode.
• Global Assessment of Function (GAF) score of \> 46 • 5 years after the first episode of MD • DSM IV criteria for a current Major Depressive Episode (MDE) diagnosed by structured clinical interview for DSM IV. Diagnosis will be confirmed by two independent psychiatrists. • Current episode of MD \> two years duration OR a history of more than 4 lifetime depressive episodes. • Minimum score at study entry of 28 on the 24-item Hamilton Depression Rating Scale (HDRS24).
• Average pre-operative HDRS24 score of 28 or greater (averaged over screening period) and a final preoperative HDRS24 score no more than 30% lower than the baseline screening HDRS score. • Treatment-resistant depression defined as: • Failure to respond to a minimum of four different antidepressant treatments, including medications and evidence-based psychotherapy (\> 20 sessions with an experienced psychotherapist) administered at adequate doses and duration during the current episode. We will require documentation (i.e., statement from the treating psychiatrist) that a treatment trial has failed (either no response to maximum tolerable doses for a minimum of 5 weeks, or side-effects at sub-maximal doses) as coded by the Antidepressant Treatment History Form (ATHF). The study investigators will document each treatment by way of review of records from referring psychiatrists. • Failure or intolerance of an adequate course of electroconvulsive therapy (ECT) during any episode (\> 6 bilateral treatments).
• A patient may remain on psychotropic medications during this study. However, doses must remain stable during a one month pre-operative evaluation period, the single blind phase and the open stimulation phase.
• If currently in psychotherapy, a patient must have been in this therapy for at least six months and continue to attend scheduled visits at no greater or lesser frequency than during the last three months. -
• Patients must have an established outpatient psychiatrist.
• Patients are able to fulfill the study requirements.
• Patients are in good general health.

You may not qualify if:

• Inability to tolerate general anesthesia.
• Any current clinically significant neurological disorder or medical illness affecting brain function, other than motor tics or Gilles de la Tourette syndrome
• Any clinically significant abnormality on preoperative magnetic resonance imaging (MRI)
• Cerebrovascular risk factors or a previous stroke, documented head trauma or neurodegenerative disorders.
• Other clinically significant Axis I psychiatric diagnoses including schizophrenia, bipolar I disorder (patients with bipolar II disorder will be included), panic disorder, obsessive-compulsive disorder, generalized anxiety disorder or post-traumatic stress disorder in the previous 12 months. Patients with severe Axis II personality disorders will also be excluded if they have the potential to interfere with cooperation during the pre- and post-operative phases of the study.
• Current psychotic symptoms.
• Current mixed episode.
• Evidence of global cognitive impairment.
• Substance abuse or dependence within the last year (except nicotine).
• Active suicidal ideation.
• Pregnancy and women of childbearing age not using effective contraception or currently nursing.
• General contraindications for DBS surgery (impossibility to conduct pre-operative fMRI, infections, claustrophobia, pregnancy, impossibility to stay awake during electrode implantation, medical risks regarding the operation, cardiac pacemaker/defibrillator or other implanted devices).
• Inability or unwillingness to comply with long-term follow-up.
• Patients who are not able to read and understand the consent form, or who are not capable of understanding or giving informed consent to the procedures of the study.
• History of intolerance to stimulation of any area of the body

Sponsors & Collaborators

• University Hospital, Bonn: lead

Study Sites (1)

Department of Psychiatry and Psychotherapy - University Hospital

Bonn, 53105, Germany

Location

MeSH Terms

Conditions

Bipolar Disorder

Interventions

Deep Brain Stimulation

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Surgical Procedures, Operative

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Psychiatry and Psychotherapy

Study Record Dates

• First Submitted: May 6, 2011
• First Posted: June 14, 2011
• Study Start: May 1, 2010
• Primary Completion: May 1, 2012
• Study Completion: May 1, 2012
• Last Updated: August 7, 2018

Record last verified: 2018-08

Locations

DE (1)